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From thousands of SVS to a handful of candidate genes

BioNano Genomics

Mar 1, 2018

Bionano’s Variant Annotation Pipeline (VAP) saves researchers valuable time (and frustration) by annotating structural...

Protectome analysis: A new selective tool for bacterial vaccine discovery

Acea Biosciences

Feb 28, 2018

New generation vaccines are in demand to include only the key antigens sufficient to confer protective immunity among...

A novel real time imaging platform to quantify Macrophage Phagocytosis


Feb 26, 2018

Phagocytosis is a specific form of endocytosis by which cells engulf and internalize solid matter. Macrophages,...

How to build the largest genome ever, in 3 easy steps

BioNano Genomics

Feb 23, 2018

Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined...

Mar 19, 2018

Timelapse imaging of Drosophila melanogaster larva's central nervous system


Feb 22, 2018

Drosophila melanogaster is a well-established model organism to understand biological processes and study human...

High-throughput observation of molecular motor activity & dynamics


Feb 21, 2018

With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells

Acea Biosciences

Feb 19, 2018

To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen...

Mar 19, 2018

BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients

BioNano Genomics

Feb 15, 2018

In a publication in Genome Medicine, a team of researchers from Children’s National Health Center and University of...

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A novel high throughput assay for diagnosis by real-time monitoring of parasite motility

Jun 7, 2017

Here we describe a novel application for a real-time cell monitoring device (xCELLigence) that can simply and objectively assess anthelmintic effects by measuring parasite motility in real time in a fully automated high-throughput fashion. We quantitatively assessed motility and determined real time IC50 values of different anthelmintic drugs against several developmental stages of major helminth pathogens of humans and livestock, including larval Haemonchus contortus and Strongyloides ratti, and adult hookworms and blood flukes. The assay enabled quantification of the onset of egg hatching in real time, and the impact of drugs on hatch rate, as well as discriminating between the effects of drugs on motility of drug-susceptible and –resistant isolates of H. contortus.

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Scientific paper

Related technologies: Real-time, Label Free Cell Analysis

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Riccardo Pasculli

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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A unique, portable, impedance-based system for cell-based assays, such as cell growth, proliferation, cytotoxicity, adhesion and morphological dynamics

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The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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