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Examining the kinetics of Neutrophil phagocytosis by flow cytometry

Acea Biosciences

Nov 20, 2017

The immune system has evolved specialized cells which engulf and kill invading pathogens in a process known as...

C-Trap and AFS systems mentioned in two review articles

LUMICKS

Nov 16, 2017

We are proud to announce two review articles refering to LUMICKS; one highlighting the C-Trap Optical...

Charting the dark matter of cancer genomes

BioNano Genomics

Nov 6, 2017

Researchers like Dr. Broach, Director of the Penn State Institute for Personalized Medicine use Bionano genome mapping...

Micronucleus test using CQ1 confocal quantitative image cytometer

Yokogawa

Nov 3, 2017

Micronucleus test is carried out to evaluate the genotoxicity of chemical substances. Micronucleus is a smaller nucleus...

Nov 20, 2017

Lung and heart cyclical imaging, simplified

Bruker Biospin

Nov 2, 2017

Movement in a microCT scan leads to movement artefacts which degrade image quality. However, imaging of breathing lungs...

Polymerase chain reaction: the past, present and future

BJS Biotechnologies

Oct 31, 2017

PCR is now a standard tool in research. BJS Biotechnologies has created an ultra-high speed thermal cycler, known as...

In vivo visualization of Candida albicans infections

Bruker Biospin

Oct 30, 2017

The Bruker In-Vivo Xtreme II instrument offered the flexibility of multimodal in vivo imaging as well as a temperature...

Nov 20, 2017

Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia

Acea Biosciences

Oct 25, 2017

Hyperthermic intraperitoneal chemotherapy (HIPEC) is proposed as a promising treatment method, but fundamental...

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Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy

Sep 12, 2017

Using standard cell lines, although attractive, can lead to unexpected results and probably to important differences when investigating a drug in primary cell lines isolated from patients. The opportunity to use cells of human origin may improve the predictive value of assays in drug testing and came hand in hand with the development of innovative real-time monitoring of cellular behaviour.

xCELLigence real time cell analyser offers a label-free non-invasive manner long-term recording of cellular signals. Considering all this aspects, the aim of our research was to evaluate the impedance of the primary melanocytes isolated from excised tumours that were confirmed as cutaneous melanoma. Primary cell cultures were used for establishing the efficacy pattern of a standard cytostatic, dacarbazine.
Our goal stands for obtaining a work flow for validating specific drug’s efficacy in individual tumour cells as a mean to personalize therapy in melanoma.

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Scientific paper

Related technologies: Real-time, Label Free Cell Analysis

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Riccardo Pasculli

Field Application Specialist

Riccardo

Pasculli

+420 731 127 717

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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A unique, portable, impedance-based system for cell-based assays, such as cell growth, proliferation, cytotoxicity, adhesion and morphological dynamics

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The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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