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How to build the largest genome ever, in 3 easy steps

BioNano Genomics

Feb 23, 2018

Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined...

Timelapse imaging of Drosophila melanogaster larva's central nervous system

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Drosophila melanogaster is a well-established model organism to understand biological processes and study human...

High-throughput observation of molecular motor activity & dynamics

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With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells

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To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen...

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BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients

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In a publication in Genome Medicine, a team of researchers from Children’s National Health Center and University of...

Label-free, real-time live-cell assays for spheroids: IncuCyte bright-field analysis

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A  growing  body  of  evidence  suggests  that  more  relevant  and  translational  observations  can  be  made  with ...

Measuring absolute blood perfusion in mice using dynamic contrast-enhanced ultrasound

VisualSonics FujiFilm

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Contrast-enhanced ultrasound imaging involves the injection of gas-filled microbubbles that do not extravasate. This...

Feb 25, 2018

Nanoparticle-uptake behavior in two standard cell lines, NIH/3T3 and A549

Etaluma

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The uptake of nanomaterials into different cell types is a key issue for the determination of nanotoxicity as well as...

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Design and analysis of single-cell sequencing experiments

Apr 21, 2016

Recent advances in single-cell sequencing hold great potential for exploring biological systems
with unprecedented resolution. Sequencing the genome of individual cells can reveal somatic mutations
and allows the investigation of clonal dynamics. Single-cell transcriptome sequencing can
elucidate the cell type composition of a sample. However, single-cell sequencing comes with major
technical challenges and yields complex data output. In this Primer, we provide an overview of
available methods and discuss experimental design and single-cell data analysis. We hope that
these guidelines will enable a growing number of researchers to leverage the power of single-cell
sequencing.

Scientific paper
Application

Related technologies: Automated Single-cell Genomics

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Fluidigm

Fluidigm is a Molecular and Single Cell Biology company that creates microfluidic-based chips and instrumentation for Life-Science research.

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The first automated solution for single-cell genomics, now capable of even more

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