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From thousands of SVS to a handful of candidate genes

BioNano Genomics

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Bionano’s Variant Annotation Pipeline (VAP) saves researchers valuable time (and frustration) by annotating structural...

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Timelapse imaging of Drosophila melanogaster larva's central nervous system


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High-throughput observation of molecular motor activity & dynamics


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With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells

Acea Biosciences

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To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen...

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BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients

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In a publication in Genome Medicine, a team of researchers from Children’s National Health Center and University of...

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F.I.S.H. analysis using ImageStream, multispectral imaging flow cytometry

Aug 12, 2016

Amnis Corporation has developed the ImageStream multispectral imaging flow cytometer. The platform combines the morphological capabilities of multiple forms of microscopy with the sample handling and quantitative power of flow cytometry. The high throughput capabilities of the ImageStream instrument are well suited for chromosomal Fluorescent In Situ Hybridization (FISH) analysis of large numbers of cells. Amnis’ IDEAS software package allows quantitative, objective spot counting and analysis. In order to convert from a slide format to a flow format Amnis has developed FISH In Suspension (FISH-IS) protocols. Applications include the detection of aneuploidy in sperm and other cell types, detection of gene amplification and translocation associated with cancer, and detection of residual disease after bone marrow transplantation. Presented is the high throughput quantitation of aneuploidy in human sperm using probes for chromosomes 8 and Y. 

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Riccardo Pasculli

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Amnis has created the ImageStream Cell Analysis System, a breakthrough technology for high speed imaging and analysis of cells in flow.

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