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From thousands of SVS to a handful of candidate genes

BioNano Genomics

Mar 1, 2018

Bionano’s Variant Annotation Pipeline (VAP) saves researchers valuable time (and frustration) by annotating structural...

Protectome analysis: A new selective tool for bacterial vaccine discovery

Acea Biosciences

Feb 28, 2018

New generation vaccines are in demand to include only the key antigens sufficient to confer protective immunity among...

A novel real time imaging platform to quantify Macrophage Phagocytosis


Feb 26, 2018

Phagocytosis is a specific form of endocytosis by which cells engulf and internalize solid matter. Macrophages,...

How to build the largest genome ever, in 3 easy steps

BioNano Genomics

Feb 23, 2018

Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined...

Mar 19, 2018

Timelapse imaging of Drosophila melanogaster larva's central nervous system


Feb 22, 2018

Drosophila melanogaster is a well-established model organism to understand biological processes and study human...

High-throughput observation of molecular motor activity & dynamics


Feb 21, 2018

With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells

Acea Biosciences

Feb 19, 2018

To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen...

Mar 19, 2018

BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients

BioNano Genomics

Feb 15, 2018

In a publication in Genome Medicine, a team of researchers from Children’s National Health Center and University of...

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High-throughput imaging: focusing in on drug discovery in 3D

Jun 14, 2017

3D organotypic culture models such as organoids and multicellular tumor spheroids (MCTS) are becoming more widely used for drug discovery and toxicology screening. As a result, 3D culture technologies adapted for high-throughput screening formats are prevalent. While a multitude of assays have been reported and validated for high-throughput imaging (HTI) and high-content screening (HCS) for novel drug discovery and toxicology, limited HTI/HCS with large compound libraries have been reported. Nonetheless, 3D HTI instrumentation technology is advancing and this technology is now on the verge of allowing for 3D HCS of thousands of samples. This review focuses on the state-of-the-art high-throughput imaging systems, including hardware and software, and recent literature examples of 3D organotypic culture models employing this technology for drug discovery and toxicology screening.

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Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. We invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.

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