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From thousands of SVS to a handful of candidate genes

BioNano Genomics

Mar 1, 2018

Bionano’s Variant Annotation Pipeline (VAP) saves researchers valuable time (and frustration) by annotating structural...

Protectome analysis: A new selective tool for bacterial vaccine discovery

Acea Biosciences

Feb 28, 2018

New generation vaccines are in demand to include only the key antigens sufficient to confer protective immunity among...

Follow biological processes in vivo at the cellular level

Mauna Kea Technologies

Feb 27, 2018

Cellvizio Lab uses unique probe-based Confocal Laser Endomicroscopy technology. Watch this recorded webinar to learn...

A novel real time imaging platform to quantify Macrophage Phagocytosis


Feb 26, 2018

Phagocytosis is a specific form of endocytosis by which cells engulf and internalize solid matter. Macrophages,...

Mar 19, 2018

Timelapse imaging of Drosophila melanogaster larva's central nervous system


Feb 22, 2018

Drosophila melanogaster is a well-established model organism to understand biological processes and study human...

High-throughput observation of molecular motor activity & dynamics


Feb 21, 2018

With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells

Acea Biosciences

Feb 19, 2018

To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen...

Mar 19, 2018

BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients

BioNano Genomics

Feb 15, 2018

In a publication in Genome Medicine, a team of researchers from Children’s National Health Center and University of...

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How to build the largest genome ever, in 3 easy steps

Feb 23, 2018

The axolotl is an odd creature. It never really grows up and stays in its larval stage throughout life. It looks like an anime character. It regenerates limbs effortlessly. And it has the largest genome ever assembled: 32 gigabasepairs – that’s ten times the size of a human genome.
Where do you even start to assemble such a monstrously large genome? You take 3 easy steps:
Step 1, you use Bionano’s high throughput Saphyr to build 2 complete maps of the genome, based on separate labeling of two sequence motifs.
Step 2, you use these maps to anchor sequence contigs generated from 32x PacBio coverage using a custom built assembler, error corrected with 7x Illumina short reads.
Step 3, you use the Bionano maps to resolve 4,828 chimeric contigs. And to be honest, that happens automatically as part of step 2.

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Scientific paper

Related technologies: Genome Mapping

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BioNano Genomics

A revolutionary NanoChannel technology for Genome mapping of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias.

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Genome maps of extremely long DNA without amplification, providing long-range contiguity and eliminating PCR bias

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Saphyr provides rapid, high-throughput, long-range genome mapping with unmatched structural variation discovery capabilities

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