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How to build the largest genome ever, in 3 easy steps

BioNano Genomics

Feb 23, 2018

Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined...

Timelapse imaging of Drosophila melanogaster larva's central nervous system

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Drosophila melanogaster is a well-established model organism to understand biological processes and study human...

High-throughput observation of molecular motor activity & dynamics

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With LUMICKS’ C-Trap, it is possible to observe myosin activity,the processive motion, the binding kinetics along...

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BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients

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In a publication in Genome Medicine, a team of researchers from Children’s National Health Center and University of...

Label-free, real-time live-cell assays for spheroids: IncuCyte bright-field analysis

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A  growing  body  of  evidence  suggests  that  more  relevant  and  translational  observations  can  be  made  with ...

Measuring absolute blood perfusion in mice using dynamic contrast-enhanced ultrasound

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Contrast-enhanced ultrasound imaging involves the injection of gas-filled microbubbles that do not extravasate. This...

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Nanoparticle-uptake behavior in two standard cell lines, NIH/3T3 and A549

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The uptake of nanomaterials into different cell types is a key issue for the determination of nanotoxicity as well as...

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Identification of liver metastases with confocal laser endomicroscopy at two excitation wavelengths

Apr 7, 2017

Metastasis of colorectal cancer to the liver is the most common indication for hepatic resection in a western population. Incomplete excision of malignancy due to residual microscopic disease normally results in worse patient outcome. Therefore, a method aiding in the real time discrimination of normal and malignant tissue on a microscopic level would be of benefit.
The ability of fluorescent probe-based confocal laser endomicroscopy to identify normal and malignant liver tissue was evaluated in an orthotopic murine model of colorectal cancer liver metastasis. To maximise information yield, two clinical fluorophores, fluorescein and indocyanine green were injected and imaged in a dual wavelength approach (488 and 660 nm, respectively). Visual tissue characteristics on probe-based confocal laser endomicroscopy examination were compared with histological features. Fluorescence intensity in both tissues was statistically analysed to elucidate if this can be used to differentiate between normal and malignant tissue.

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Related technologies: Probe based Confocal Microscopy

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Mauna Kea Technologies

Mauna Kea Technologies manufactures Cellvizio Lab, confocal probe based imaging system, providing cellular-level images with minimal invasiveness for longitudinal studies.

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Cellvizio, a fiber based microscope for observing in real time at cellular scale, features simultaneous, co-registered dual band excitation and detection

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