Accelerate to Discover

Back to filter

Related topics

Inhibition of T cell receptor signaling mediated Calcium flux in T cells

Apr 23, 2018

Calcium (Ca2+) is an important secondary messenger and a key component of many cell processes. It is an extremely...

High-resolution and high-sensitivity PET imaging of cardiovascular disease

Bruker Biospin

Apr 20, 2018

In this paper, Bruker report the recent progress in preclinical PET hardware development enabling now to reach...

Rapid, accurate diagnosis of Clostridium difficile infections

BJS Biotechnologies

Apr 19, 2018

Real-time PCR of toxin genes has been shown to be the most effective diagnostic method for accurate and early diagnosis...

3D culture systems for 3D world

Synthecon

Apr 18, 2018

Synthecon, Incorporated is a biotechnology company that specializes in the design and manufacture of 3D cell culture...

Apr 24, 2018

Target large genomic regions with 10x genomics using SageHLS

Sage Science

Apr 16, 2018

With customized Cas9 nucleases, scientists can now isolate specific large genomic DNA fragments with the SageHLS...

Expert-led didactic versus self-directed audiovisual training of confocal laser endomicroscopy

Mauna Kea Technologies

Apr 16, 2018

This randomized controlled study involved trainee analysts who were taught how to recognize mucosal barrier defects on...

Evaluation of quantum dot toxicity on three-dimensional spheroid using Lumascope720

Etaluma

Apr 12, 2018

In this work, three-dimensional (3D) spheroid cultures of human adipose-derived mesenchymal stem cells (hAD-MSCs), with...

Apr 24, 2018

This tiny robot walks, crawls, jumps and swims. But it is not alive.

VisualSonics FujiFilm

Apr 9, 2018

This tiny robot walks, crawls, jumps and swims. But it is not alive. Read this interesting article about new kind of...

Show all topics (10)

The effects of hypoxia and hydrostatic pressure in translational research

Apr 16, 2018

The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.

Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.

Application
Product news

Related technologies: Physiological cell culturing

Get more info

Riccardo Pasculli

Field Application Specialist

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

Related products

The Avatar system can mimic the oxygen and pressure levels of human tissues

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey