Accelerate to Discover

Digital measurement for HER2 amplifcation in HER2 equivocal breast cancer diagnosis

Wang et al in their paper have compared 2 diferent dPCR platforms and the accuracy of dPCR compared with the standard techniques. Additionally, they have examined the usefulness of dPCR to determine HER2 amplifcation in IHC 2+cases.

Sep 20, 2017

Scientific paper
Application

Linked-read sequencing combined with optical mapping produce a high quality mammalian genome

Here, we have evaluated two technologies for assembling a de novo mammalian genome of the Hawaiian monk seal, an endangered species endemic to the Hawaiian islands, using techniques that interrogate individual long DNA molecules.

Sep 18, 2017

Scientific paper
Technical breakthrough
Application

Accelerate your biomedical research

The xCELLigence system proved to be a unique and invaluable technology in the development of new therapeutics for the steroid hormone sensitive cancers. It enabled us to analyze detailed proliferation dynamics of various cancer cell types, in response to manipulation of complex signaling network by steroid hormone receptors and enzymes involved in the steroid hormone biosyntesis."

Dr. David Sedlák

Institute of Molecular Genetics of the ASCR, Prague, Czech Republic

Whole genome optical mapping reveals multiple fusion events chained by novel sequences in cancer

Bionano Genomics optical mapping helps you reveal hidden structur variations (SVs). In cancer, acquired SVs have been used for molecular sub-classification and shown to be predictive of cancer progression and treatment response.

Sep 5, 2017

Scientific paper
Application

Red-shifted firefly luciferase optimized for Candida albicans in vivo bioluminescence imaging

Candida albicans is a major fungal pathogen causing life-threatening diseases in immuno-compromised patients. As these infections have a 40–60% mortality rate, there is a real need for novel therapeutic approaches.

Sep 15, 2017

Scientific paper
Technical breakthrough
Application

Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy

There are a few literature data focusing on impedance measurement of melanocytes’ cellular behaviour. We present herein the impedance measurement as a potential assay for studying the sensitivity of melanocytes, isolated from freshly excised tumours.

Sep 12, 2017

Scientific paper

Accelerate your biomedical research

"The Cellvizio Dual Band is capable of achieving cell to sub-cell resolution in vivo, from surface to deep tissues. The system allow us to monitor multiple dynamic processes, physiological pathways or cellular interactions in vivo in the same animal over longitudinal studies."

Assoc.Prof. M.D. Jakub Otáhal

Czech Academy of Sciences, Institute of Physiology, Prague, Czech Republic

Real-time, dynamic measurements of cellular migration & controlled microenvironmental conditions

Cellular migration is an important biological process that occurs in both in health and disease as a part of wound healing, development, differentiation, inflammation, immune response, angiogenesis and metastasis.

Sep 13, 2017

Scientific paper
Technical breakthrough
Product news

Timelapse analysis of cell migration using CQ1 confocal quantitative image cytometer

The scratch assay is one of the most commonly used methods to evaluate the cellular capability of infiltration and proliferation. The multicolor time-lapse imaging by CQ1 offers the quantitative analysis of cell migration and proliferation with time.

Sep 6, 2017

Scientific paper
Application
Product news

In vivo imaging of the Muc5b gel-forming mucin

Gel-forming mucins are macromolecules produced by goblet cells and responsible for the mucus gel formation. Changes in goblet cell density and in gel-forming mucin production have emerged as sensitive indicators for mucosal diseases.

Aug 8, 2017

Scientific paper
Application

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