Cellular analysis

Real-time, Label Free Cell Analysis
Riccardo Pasculli

Field Application Specialist

Riccardo

Pasculli

+420 731 127 717

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Real-time, label free cell analysis

For both high-throughput screening and research laboratory environments

The xCELLigence System from ACEA Biosciences is a microelectronic biosensor system for cell–based assays, providing dynamic, real-time, label-free cellular analysis for a variety of research applications in drug development, toxicology, cancer, medical microbiology and virology. This technology allows researchers to increase productivity and exceed the limits of endpoint analysis by capturing data throughout the entire time course of an experiment and obtaining more physiologically relevant data. Choose from multiple instrument formats and benefit from cost-effective, user-friendly cell-based assays designed to analyze compound effects in a context as close as possible to the natural environment.  

The presence of the cells on top of the electrodes affects the local ionic environment at the electrode/solution interface, leading to an increase in the electrode impedance. The more cells are attached on the electrodes, the larger the increases in electrode impedance. In addition, the impedance depends on the quality of the cell interaction with the electrodes. For example, increased cell adhesion or spreading will lead to a larger change in electrode impedance. Thus, electrode impedance, which is displayed as cell index (CI) values, can be used to monitor cell viability, number, morphology, and adhesion degree in a number of cell-based assays.

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Real-time, Label Free Cell Analysis products

A unique, portable, impedance-based system for cell-based assays, such as cell growth, proliferation, cytotoxicity, adhesion and morphological dynamics

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The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing

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The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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Live Cell Imaging in Your Incubator

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Real-time automated measurements of cell health, movement and function, inside your incubator

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