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"xCELLigence system helped my research in performing real-time evaluation of the toxicological profile for several types of innovative drugs that were tested on both primary cells and standard cell lines. Additionally, this platform demonstrated high sensitivity of detection of intracellular signaling events for drugs targeting protein kinases-mediated cellular pathways."

Dr. Monica Neagu

'Victor Babeș' National Institute of Pathology, Bucharest, Romania

"The xCELLigence RTCA SP analysis is without any doubts a proven non-invasive and sensitive method for monitoring the viability, proliferation or migration of cells in real time and thus complements and explains a number of end-point experiments. Our laboratory deals with the study of new natural molecules or compounds prepared semisynthetically. The analysis software is also intuitive and complete, moreover, ACCELA as a local supplier is able to provide qualified training and service."

Dr Darja Koutová

Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic

"We purchased the system as we had a good experience with it in past – our group works in the field of nanomedicine. In experiments, various nanomaterials (carbon, magnetic particles) are modified by antitumor drugs and other molecules for specific targeting of tumor cells.
The the greatest benefit of the system is that the experiments are easy to set up, the data are obtained in a relatively short time without the need for more complicated sample manipulation. The method makes it possible not only to monitor the increasing number of cells, but also to evaluate the progress of this process - to elegantly determine the growth characteristics of the studied cells and to test the substances used. The process is completely independent of the human factor, thereby minimizing common experimental errors."

Prof. René Kizek

University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

„Our researches are mostly focused in the context of type II Diabetes, Obesity and a broad range of applications in cell biolabeling, cancer treatment, metastasis and therapeutic drug monitoring. Compared to traditonal end-point method, xCelligence system revolutionized our workflow adding real-time monitoring of cells inside incubator as an fundamental factor to assess long term effect of different compounds of interest."

Dr Marta Kepinska

Wroclaw Medical University, Poland

“The iCELLigence system provides me a fast, reliable and reproducible way to specifically monitor the suspension cell interactions with proteins of the extracellular matrix, and dynamics of its changes in response to inhibitor addition”

Dr. Adam Obr

Institute of Hematology and Blood Transfusion, Prague, Czech Republic

xCELLigence SP - Agilent technologies

Basic tool with a huge impact for any cell based assay

The RTCA SP Station is located inside a tissue culture incubator and is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement. Under the software of the RTCA Control Unit, the RTCA SP Analyzer can automatically select wells for measurement and continuously transfer measured impedance data to the computer. Cell Index values, derived from the measured impedances, are continuously displayed on the Software user interface.

The RTCA SP Instrument is composed of four main components:

  • RTCA Analyzer
  • RTCA SP Station
  • RTCA Control Unit
  • E-Plate 96

RTCA SP Instrument Highlights:

  • Rapid measurement time - less than 10 or 60 seconds for 96 wells
  • Compact design of the RTCA SP Station that fits conveniently in tissue culture incubators
  • High-performance electronic components and enhanced instrument reliability
  • Easy setup and customization of assay protocols
  • Integrated, on-line data analysis capability

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https://www.aceabio.com/products/rtca-sp/

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Cancer Immunotherapy Applications of xCELLigence Real-Time Cell Analysis (RTCA) Systems xCELLigence cancer immunotherapy: NK cell-mediated cytolysis Real-time chemotaxis of macrophages Quantifying virus-mediated cytopathic effect with xCELLigence platform Introducing the xCELLigence Immunotherapy kit – B Cell killing assay Real-time monitoring of Human Skin-Derived Precursor (SKPs) cell differentiation Assessment of CAR T Cell killing capacity against solid tumors-Thursday, October 20, 2016, 5 pm CEST Cancer immunotherapy: Macrophage-mediated phagocytosis Monitoring in real time the formation and removal of biofilms from clinical related pathogens xCELLigence in personalized cancer medicine Investigating the hallmarks of cancer using xCELLigence system Monitoring the formation and removal of biofilms from clinically relevant pathogens in real-time Real-time determination of virus titers using cell electric impedance technology Label-free monitoring of T cell activation by the impedance-based system A novel high throughput assay for diagnosis by real-time monitoring of parasite motility Optimization of (CAR) T cell design guided by sensitive sssessment of B cell killing Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia ACEA webinar series: Using xCELLigence RTCA to study biofilms formation Protectome analysis: A new selective tool for bacterial vaccine discovery Kinase study of cytotoxicity voted paper of the year. ACEA Biosciences launch xCELLigence RTCA software Pro for immunotherapy applications New technique for dynamic monitoring of liquid tumor Cytotoxicity xCELLigence system: rapid and sensitive, ideal for infectious viral assays.
Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

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