The Cell200 combines the strengths of both high quality biochemical and cell-based assays in one system. Continuous flow and temperature control provide a full dynamic profile of the interaction to be studied, label-free and in an idealized in vitro-environment, in real time. This means that interactions can now be analyzed in the natural biological context with unmodified crude biological samples and directly on the cell surface. Cells can be cultivated directly on Attana’s proprietary cell surface or captured from cell suspension before analysis. As ligands interacts with the intact cell in real time, the system captures the complete dynamics and complexity of the interaction, generating data of high information content.
The ability to cultivate, treat and analyze the cells directly on the sensor surface minimizes handling and perfects cell conditioning. Two parallel channels give the possibility to run the experiment in duplicate or use one channel as external reference. Automation and controlled sample storage ensures system stability and sample integrity, this together with robust fluidics allows unattended long runs.
The Attana Cell 200 system also has all the features of the Attana A200 system and the benefit of being able to run all of Attana’s wide range of sensor chip surfaces.
