Accelerate to discover

Homepage>Discover>Assessment of CAR T Cell killing capacity against solid tumors-Thursday, October 20, 2016, 5 pm CEST

Dec 4, 2019

Micro-CT is a powerful tool for the longitudinal monitoring of bones to acquire bone mass and architectural changes in...

Bioflux webinar: Flow dynamics influence on biofilm formation by Proteus mirabilis

Dec 2, 2019

Catheter blockage by ureolytic biofilm-forming pathogens is a significant problem for health services, with 2,000...

Webinar recording: Advancing spectral flow cytometry data analysis with new SpectroFlo 2.2 & FCS Express 7

Nov 27, 2019

Learn about new SpectroFlo version 2.2.0. Innovative software tools from Cytek Biosciences and De Novo Software that...

Preclinical hyperpolarized carbon-13 magnetic resonance imaging in neurological disease models

Nov 8, 2019

Hyperpolarized (HP)-13C MR is proven as a viable tool for imaging of neurological disorders often associated with...

Jan 25, 2020

Imaging Flow Cytometry webinar: aging cells, giant viruses using AMNIS platform

Nov 6, 2019

In this webinar we will describe three recent applications for imaging flow cytometry (IFC), a technology that combines...

Webinar recording: Use of ultra-high field MRI for in and ex vivo neuroimaging

Nov 6, 2019

The relatively low T1 contrast, long T1 values at higher fields lead to the necessity to adapt sequences commonly used...

Join the webcast: Addressing cancer gene therapy efficacy with IncuCyte Live–Cell Imaging

Oct 29, 2019

During this webinar, Dr Pierre Cordelier will discuss the use of IncuCyte Live-Cell Imaging and Analysis, to track gene...

Jan 25, 2020

Acquisition and analysis of reproducible high-complexity cytometry data using the Cytek Aurora

Oct 8, 2019

We invite you to join us on Friday, October 11 at 8:00 PM CET to hear more about Cytek collaborative...

Show all topics (10)

Assessment of CAR T Cell killing capacity against solid tumors-Thursday, October 20, 2016, 5 pm CEST

Oct 13, 2016

Nabil Ahmed, M.D., M.P.H. Associate Professor of Pediatrics, Baylor College of Medicine (USA).

Robust CAR design and sensitive yet realistic functional testing will be required in order to improve the efficacy of CAR T cell therapies targeting solid tumors. We have used the xCELLigence Real-Time Cell Analyzer as a high-throughput platform to test multiple CAR components including extracellular domains (including bi-specifics), signaling endo-domains, as well as next-generation CAR T cell products that are inherently resistant to checkpoint blockade. This platform has proven very sensitive to subtle yet longitudinally meaningful differences in CAR design, and has made it possible to evaluate T cell products in a "stress test" that is more representative of early phase trial requirements.

Register now

Webinar

Related technologies: Real-time, label free cell analysis

Get more info