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Assessment of pro-arrhythmic effects using xCELLigence Cardio system and Pluricyte Cardiomyocytes

Aug 21, 2019

This application note describes our recommendations for the analysis of Pluricyte Cardiomyocytes electrophysiology by MEA and impedance measurements using the xCELLigence RTCA Cardio ECR system (ACEA Biosciences). In addition, a case study describing the assessment of the effects of a set of pro-arrhythmic compounds in Pluricyte Cardiomyocytes, showing the expected pharmacological responses, is provided in this document. Cardiomyocytes, cultured in Pluricyte Cardiomyocyte Medium, in combination with the xCELLigence RTCA CardioECRsystem provide a highly relevant in vitro assay platform to study the cardiac safety profile of compounds during drug development.