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Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice

Precision X-Ray

Dec 28, 2020

Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have...

EV imaging series: Using ONI super-resolution to characterize single-EVs

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To date, researchers commonly use flow-based characterization methods, fluorescence imaging techniques and electron...

Don’t Let Waste Anesthetic Gases Harm You!

RWD

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Many projects have been devoted to the study of the correlation between anesthetics and Alzheimer’s disease....

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Ever wanted to take your full spectrum panel from your Cytek Aurora or Northern Lights cytometer and sort? Soon, you...

Dec 30, 2020

Advances in Leukemia research using shear flow and Bioflux system

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Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Do you have our CellRad benchtop irradiator? It’s the only one on the market!

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The CellRad is a smaller, simpler, safer, and more cost effective alternative to radioisotope or high-powered X-ray...

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Cancer immunotherapy: Macrophage-mediated phagocytosis

Oct 27, 2016

In a recent study the secreted glycoprotein thrombospondin 1 (TSP1) was shown to be a positive modulator of innate antitumor immunity by increasing M1 macrophage recruitment and stimulating reactive oxygen species (ROS)-mediated tumor cell killing. These conclusions were drawn, in part, by using xCELLigence RTCA impedance monitoring to evaluate the effect of TSP1 on macrophage/ monocyte activity when co-cultured with MDA-MB-231 breast adenocarcinoma target cells. The % cytolysis data clearly indicate that the tumoricidal activity of both differentiated U937 human monocytes and activated ANA-1 murine macrophages  are enhanced in the presence of TSP1.

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Agilent technologies

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Located inside a tissue culture incubator, the RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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