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Outstanding post-sort sample recovery on the WOLF Cell Sorter

NanoCellect

Jun 14, 2022

The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters

MOLECUBES

Jun 3, 2022

Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...

An experimental strategy for preparing circular ssDNA virus genomes for next-generation sequencing

Sage Science

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Recent article from February 2022 shoes how size selection improved viral read mapping by over 90% for begomoviruses.

Extracellular Vesicle Purity Enhanced by Gen 2 qEV Columns With Customised Proprietary Resin

IZON

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Izon Science has announced the launch of Gen 2, the enhanced range of qEV columns for size-exclusion...

Jul 5, 2022

Multi-modal PET drives interdisciplinary preclinical imaging

Bruker Biospin

Feb 23, 2022

Preclinical imaging (PCI) plays a vital role in understanding the biological processes behind disease states at the...

Quantitative 3D Optical Imaging for Lago

Spectral Instruments Imaging

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Spectral Instrument Imaging just announced a new, strategic partnership with InVivo Analytics, which enables...

Reduces fMRI-BOLD Response in the Brain

Bruker Biospin

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fMRI studies often involve the electrical stimulation of i.e. the forepaw, detecting where this stimulation is...

Jul 5, 2022

Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer

Agilent technologies

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Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...

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Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy

Sep 12, 2017

Using standard cell lines, although attractive, can lead to unexpected results and probably to important differences when investigating a drug in primary cell lines isolated from patients. The opportunity to use cells of human origin may improve the predictive value of assays in drug testing and came hand in hand with the development of innovative real-time monitoring of cellular behaviour.

xCELLigence real time cell analyser offers a label-free non-invasive manner long-term recording of cellular signals. Considering all this aspects, the aim of our research was to evaluate the impedance of the primary melanocytes isolated from excised tumours that were confirmed as cutaneous melanoma. Primary cell cultures were used for establishing the efficacy pattern of a standard cytostatic, dacarbazine.
Our goal stands for obtaining a work flow for validating specific drug’s efficacy in individual tumour cells as a mean to personalize therapy in melanoma.

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Scientific paper

Related technologies: Real-time, label free cell analysis

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Riccardo Pasculli

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Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Located inside a tissue culture incubator, the RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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