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Cell plasticity associated to circulating tumor cells from prostate cancer patients

Fluxion Biosciences

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Treatment resistance is associated with tumor cells molecular plasticity. In metastatic castration resistant prostate...

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13C-Hyperpolarized molecules provide a unique signature for molecular processes relevant to a range of disease...

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Pancreatic ductal adenocarcinoma has been increasing by 0.5% per year in the United States. This study describes the...

Responsive fluorescence probe for detection of Hypochlorous acid in live cells and animals

Spectral Instruments Imaging

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In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological samples. The...

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Improved differentiation of Retinal Organoids stem cells derived using rotating-wall vessels

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Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a...

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Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy

Sep 12, 2017

Using standard cell lines, although attractive, can lead to unexpected results and probably to important differences when investigating a drug in primary cell lines isolated from patients. The opportunity to use cells of human origin may improve the predictive value of assays in drug testing and came hand in hand with the development of innovative real-time monitoring of cellular behaviour.

xCELLigence real time cell analyser offers a label-free non-invasive manner long-term recording of cellular signals. Considering all this aspects, the aim of our research was to evaluate the impedance of the primary melanocytes isolated from excised tumours that were confirmed as cutaneous melanoma. Primary cell cultures were used for establishing the efficacy pattern of a standard cytostatic, dacarbazine.
Our goal stands for obtaining a work flow for validating specific drug’s efficacy in individual tumour cells as a mean to personalize therapy in melanoma.

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Scientific paper

Related technologies: Real-time, label free cell analysis

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Riccardo Pasculli

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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