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Imaging Performance of a multimodal module to enhance preclinical irradiator capabilities

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Upgrading an existing irradiator with such a multi-modal imaging device is a reasonable investment in laboratories...

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Insulin receptor substrate 1 is a substrate of the Pim protein kinases

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The goal of these studies was to identify Pim substrate(s) that could help define the pathway regulated by these...

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Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia

Oct 25, 2017

The purpose of this study was to investigate the cytotoxic effect of hyperthermia and cisplatin on OVCAR-3 cells in vitro. Imitating the typical clinical conditions of HIPEC, OVCAR-3 cells were exposed to hyperthermia and cisplatin for 1 h. MTT viability test, flow cytometric analysis, and real-time cell and isobologram analysis were performed. Hyperthermia up to 42˚C did not significantly increase the effect of cisplatin regarding the viability and apoptosis of OVCAR-3 cells. Moreover, an antagonistic effect of hyperthermia and cisplatin was revealed. Dr.Jasukaitiene investigation of OVCAR-3 cells, critically disputes the benefit of hyperthermia in ovarian cancer treatment. Further in vitro and in vivo research is essential for better understanding of the mechanisms of action of hyperthermia and its role in the treatment of epithelial ovarian cancer.

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Scientific paper

Related technologies: Real-time, label free cell analysis

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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