High accuracy imaging and high precision X-ray dose delivery are key factors of Image Guided Radiation Therapy (IGRT). X-RAD SmART provides the highest accuracy imaging combined with the highest X-ray dose rate in a single micro-IGRT platform. Researchers can image in multiple imaging modalities, plan and treat without repositioning the specimen. Fully-integrated fluoroscopic, CT and bioluminescent imaging with flexible image fusion combine for the most advanced multi-modality image-guided therapy. With a rapid, state-of-the-art Monte Carlo treatment planning software, a complex 3D dose calculation and beam planning is now as accurate as never before. Preclinical multi-beam and multi-target 360° radiation delivery is as advanced as clinical systems and adaptable for any radiation research study from mice to rabbits, and from hind leg xenografts to embedded metastatic orthotropic models.