Accelerate to discover

Back to filter

Related topics

Four-week individual caging of male ICR mice alters body composition without change in body mass

MEDIKORS

May 25, 2020

Could individual caging affect the physical composition of outbred mice? To investigate this, dual X-ray absorptiometry...

Detect structural variants at 1% allele fraction: Dive deeper into heterogeneous cancer samples

BioNano Genomics

May 22, 2020

To get a complete picture of highly rearranged cancer genomes in heterogeneous samples, use Bionano genome imaging...

The qNano Gold: Obtain the most detailed Information for each individual nanoparticle

IZON

May 20, 2020

The qNano Gold measures particles using the Tunable Resistive Pulse Sensing (TRPS) principle. TRPS is the most powerful...

Insulin receptor substrate 1 is a substrate of the Pim protein kinases

Spectral Instruments Imaging

May 18, 2020

The goal of these studies was to identify Pim substrate(s) that could help define the pathway regulated by these...

May 29, 2020

Webinar recording: Isolating ultra-high molecular weight (UHMW) DNA for genome analysis

BioNano Genomics

May 12, 2020

Watch the webinar from Bionano Genomics and learn the tips and tricks for isolating high quality UHMW DNA - right from...

Implementation of Micro CT in CAD/CAM dentistry for image processing and soft computing

Bruker Biospin

May 4, 2020

Present radiology devices are playing an important role in clinical dentistry but their area of application islimited...

Panel design principles to investigate COVID-19 immune response with the Cytek Aurora

Cytek Biosciences

Apr 27, 2020

Learn about the Cytek Aurora and panel design tools available to help you design high quality full spectrum cytometry...

May 29, 2020

ONI Nanoimager: Viral super-resolution microscopy inside your biosafety chamber

ONI

Apr 22, 2020

Discover unique signatures that distinguish viruses,  visualise virus budding events with certainty, understand how...

Show all topics (10)

De novo design of a biologically active amyloid

Feb 5, 2018

Most human proteins possess amyloidogenic segments, but only about 30 are associated with amyloid-associated pathologies, and it remains unclear what determines amyloid toxicity. Gallardo et al. designed vascin, a synthetic amyloid peptide, based on an amyloidogenic fragment of vascular endothelial growth factor receptor 2 (VEGFR2), a protein that is not associated to amyloidosis. Vascin recapitulates key biophysical and biochemical characteristics of natural amyloids, penetrates cells, and seeds the aggregation of VEGFR2 through direct interaction. They found that amyloid toxicity is observed only in cells that both express VEGFR2 and are dependent on VEGFR2 activity for survival. Thus, amyloid toxicity here appears to be both protein-specific and conditional—determined by VEGFR2 loss of function in a biological context in which target protein function is essential.

Read more

 

Scientific paper
Application

Related technologies: Probe based confocal microscopy

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

Mauna Kea Technologies

Mauna Kea Technologies manufactures Cellvizio Lab, confocal probe based imaging system, providing cellular-level images with minimal invasiveness for longitudinal studies.

Related products

Cellvizio, a fiber based microscope for observing in real time at cellular scale, features simultaneous, co-registered dual band excitation and detection

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey