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Homepage>Discover>Differentation displacement in acute myeloid leukemia through enhancer activation

Jan 17, 2019

In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological samples. The...

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Jan 23, 2019

ACEA Biosciences launch xCELLigence RTCA software Pro for immunotherapy applications

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RTCA Software Pro is an integrated software package for running and analyzing real time cell analysis data from...

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Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies

Dec 6, 2018

Accurate labeling of endogenous proteins for advanced light microscopy in living cells remains challenging. Nanobodies...

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Differentation displacement in acute myeloid leukemia through enhancer activation

Aug 7, 2018

LSD1 is a flavin adenine dinucleotide (FAD)-dependent homolog of the amine oxidase family and there was recently brought attention to it as a potential therapeutic target. The interest came from an observation of unusually high expression of LSD1 in certain types of poor-prognosis cancers. It was previously thought that LSD1 removes monomethyl and dymethyl histone marks. However, recently it was showed that it interacts with multiple transcripton factor. This raised a possibility of other drugs being used.

New inhibitor ORY-1001 was succesfully tested on LSD1 and blast cell differentioation was observed. The flow cytometric testing on this experiment was done with Novocyte. ORY-1001 disrupts the protein interaction between LSD1 and GFI1.

Scientific paper

Application

Related technologies: Conventional flow cytometry

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