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Dynamic PET imaging and special focus in cardiac kinetic analysis

Apr 25, 2018

Dynamic PET imaging is a powerful tool for testing and validating tracer kinetic modeling. Tracer kinetic modeling is a method for extracting transfer rate constants, volumes of distribution or binding potentials from the radiotracer to the target, by describing the mechanism of transport and biochemical reactions of the tracer in tissue. Blood samples are often taken from the animal to obtain the so-called input function. This is compared to the PET image to obtain the dynamics of the radiotracer concentration in local tissue
over time.

This document is an introductory guide to carrying out dynamic experiments with the Bruker PET Imaging portfolio. It covers experiment preparation including animal preparation, injection dose, data acquisition to image analysis. This note uses an PET FDG acquisition from a rat applied to cardiac imaging as an example of dynamic imaging, using the Albira Software Suite. However, most of the procedure will not differ greatly with other types of dynamic experiments when for instance other PET tracers are employed. In imaging systems where Paravision integrates all software interfaces, only the software acquisition and reconstruction will differ.

Do you want to learn more? Read the whole article!

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Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.

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