Accelerate to discover

Back to filter

Related topics

Identify the quality of any protein in 3 minutes using microliters of sample with Tycho


Jul 19, 2019

Tycho tells you so much about the quality of your protein. It tells you about presence, purity, concentration,...

Feel empowered with new IncuCyte SX1 live cell analysis system


Jul 17, 2019

Today’s new normal requires doing more with less. You need physiologically relevant, information-rich cell analysis...

Learning hub: Online video training for Vevo users

VisualSonics FujiFilm

Jul 15, 2019

FUJIFILM VisualSonics Learning Hub! This new online learning portal is now available exclusively for our Vevo users and...

Expanding patient tumor samples has never been so easy - Discover AVATAR

Xcell Biosciences

Jul 10, 2019

The AVATAR Cell Control System lets you fine-tune oxygen and pressure to cater culture conditions to your cell type of...

Jul 24, 2019

Linked-read sequencing advances understanding of cancers

Sage Science

Jul 8, 2019

Using Pippin HT to filter away smaller DNA fragments maximizes the efficiency of the whole genome linked-read...

Take advantage of 4D mode

VisualSonics FujiFilm

Jul 4, 2019

Cutting edgce cardiovascular research demands cutting edge technology. 4D imaging brings together dynamic motion and 3D...

Assessment of angiotensin II-induced mouse models of abdominal aortic aneurysm

VisualSonics FujiFilm

Jun 28, 2019

Are you working with high ultrasound imaging and are you interesting in progression/ regression of abdominal aortic...

Jul 24, 2019

Bionano introduce new SP blood and cell culture DNA isolation kit

BioNano Genomics

Jun 26, 2019

This Bionano prep SP blood and cell culture DNA isolation kit, can provide ultra-high molecular weight (UHMW) gDNA in...

Show all topics (10)

Fluxion Biosciences and National Cancer Institute cooperate to validate IsoFlux for sequencing

Jun 12, 2019

In a study published in PLOS One in April 2018, Ionescu-Zanetti and his colleagues compared the abilities of ERASE-Seq and those of current molecular barcoding methods. Using spiked human DNA mixed with clinically realistic DNA input quantities, the researchers sought to detect single nucleotide variants and indels between 0.05 percent and 1 percent allele frequency. They found that the tool could detect variants with greater than 90 percent sensitivity and a false positive rate below 0.1 calls per 10,000 possible variants. Jensen explained that Fluxion previously looked at other mutation caller techniques to integrate with its IsoFlux CTC isolation kits and Spotlight liquid biopsy panels, but the firm found their performance "unacceptable." He argued that the lack of high-quality callers led the group to develop and eventually release Erase-Seq in 2018, which is more of a statistical approach to identifying the true positives in a sample.

According to Jensen, Fluxion can validate a lab's panel using the Erase-Seq variant caller approach. The validation involves running a set of reference healthy samples through the firm's algorithm to develop a background model. Afterwards, the researchers run a few analytical samples to adjust the sequencing parameters, such as the depth of coverage. As part of the ongoing study, Cleveland Clinic assistant professor of radiation oncology Omar Mian and his colleagues are applying Erase-Seq to track tumor growth in a group of 30 hepatocellular cancer patients. The team is attempting to see whether the circulating tumor burden of disease and the amount of ctDNA changes before, during, or after ablative therapies (such as stereotactic radiation), surgical management like mastectomy, or tumor removal.

Read the paper, discover IsoFlux!

Technical breakthrough
Product news

Related technologies: Cell interaction studies

Get more info

Riccardo Pasculli

Head of application support



+420 731 127 717

Send Message

Brand profile

Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

Related products

The IsoFlux System is a benchtop instrument designed to isolate the    CTC´s and enrich rare cell populations

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic