Recent studies have demonstrated several clonal behaviors of cancer cells within individual pancreatic tumors, although it is unclear if this is true of metabolism. In this webinar, Dr. Chris Halbrook, Assistant Professor at the University of California Irvine, explains how his research found the metabolic profiles of a series of clonal cell lines derived from a single tumor clustered into two distinct groups. Collectively these data demonstrate distinct metabolic classes of cancer cells within single tumors and identify asparagine as a potential target to sensitize tumors to mitochondrial inhibition.
Key learning objectives:
.Clonal heterogeneity extends to metabolism
.Cancer cell growth can be supported by metabolic crosstalk
.Asparagine supports cell proliferation when respiration is impaired
.Degradation of asparagine enhances mitochondrial inhibition
Thursday, October 1, 2020, 17:00 CEST
Dr. Chris Halbrook, Assistant Professor in the Department of Molecular Biology and Biochemistry
University of California Irvine
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