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IncuCyte webinar: Evolution of 3D cell culture cancer models, advances and future outlooks

May 13, 2019

2D models, though cost effective, fail to replicate the 3D complexity of an in vivo tumor and associated influences of the tumor microenvironment, such as that of cell-to-cell contact and the influence of the extracellular matrix. These complex interactions, in combination with the unique properties of a 3D structure, affect tumor cell properties and behavior, gene expression, distribution of proteins, and ultimately, response to anticancer drugs. Spheroid models have a layered structure with rapidly proliferating cells surrounding a more quiescent and hypoxic, necrotic core. This structure generates a gradient of nutrients, metabolites, and oxygen in the spheroid, important attributes for evaluation of drug resistance due to penetration effects in a heterogeneous tumor. Effective analysis of 3D tumor spheroids can be challenging, yet models are emerging that can overcome those limitations and drive future research.

Learning objectives:
-Learn the two main approaches to generating 3D cancer models (liquid- and scaffold-based) and the   limitations for assessing the growth and shrinkage of 3D tumor spheroids
-Discover how live-cell analysis can be combined with advanced cell models for added insight and   productivity
-Glean what advances researchers can expect in the future
-Have the opportunity to ask questions during the live broadcast.

Keith L. Ligon, M.D., Ph.D., Brigham and Women’s Hospital, Boston, MA
Thursday, 16 May 2019, 6 PM Central Europe (CEST)

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Sartorius

Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. We invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.

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