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Cell plasticity associated to circulating tumor cells from prostate cancer patients

Fluxion Biosciences

Mar 13, 2019

Treatment resistance is associated with tumor cells molecular plasticity. In metastatic castration resistant prostate...

Enhanced uptake of luminescent quantum dots by live cells

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The steady progress made over the past threedecades in growing a variety of inorganic nanomaterials, with discreet...

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Bruker Biospin

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To develop and validate immuno-oncology therapies, scientists must understand the full dynamics of cytotoxic effectors...

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13C-Hyperpolarized molecules provide a unique signature for molecular processes relevant to a range of disease...

Oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts

Spectral Instruments Imaging

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Pancreatic ductal adenocarcinoma has been increasing by 0.5% per year in the United States. This study describes the...

Responsive fluorescence probe for detection of Hypochlorous acid in live cells and animals

Spectral Instruments Imaging

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In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological samples. The...

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Improved differentiation of Retinal Organoids stem cells derived using rotating-wall vessels

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Pluripotent stem cells can be differentiated into 3D retinal organoids, with major cell types self-patterning into a...

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Mechanical signalling regulates virulence in pathogenic Escherichia coli

Mar 13, 2017

Although the factors involved in colonization and disease are well characterized, how EHEC regulates its expression in response to a host encounter is not well understood. The authors report that EHEC perceives attachment to host cells as a mechanical cue that leads to expression of LEE-encoded virulence genes.The data suggest that, in addition to a range of chemical environmental signals, EHEC is capable of sensing and responding to mechanical cues to adapt to its host’s physiology.’ While this work was performed at the University of Birmingham, Dr. Krachler is currently an Associate Professor in the department of Microbiology and Molecular Genetics at UT Health, University of Texas. A long-term goal of this type of research is the reduction of deadly infection by preventing bacterial attachment to host tissues.

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Related technologies: Cell interaction studies

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With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

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