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Microvascular injury in mild traumatic brain injury accelerates alzheimer-like pathogenesis in mice

Nov 9, 2020

mTBI induced microvascular injury with BBB breakdown, pericyte loss and cerebral blood flow reduction in mice, which preceded gliosis. mTBI also impaired brain amyloid clearance via the vascular pathways. More importantly, mTBI accelerated amyloid pathology and cognitive impairment in the 5xFAD mice.

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RWD

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Real-time monitoring of two-dimensional blood flow images at the order of microns with possibility of monitoring the microvascular blood flow distribution and relative changes in the values

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