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Homepage>Discover>New study resolves helicase dynamics and interactions during DNA replication using C-Trap

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New study resolves helicase dynamics and interactions during DNA replication using C-Trap

Aug 30, 2019

Wasserman et al. analyzed the properties of fluorescently-labeled CMG during DNA replication. For this, they used optical tweezers to tether a double-stranded molecule between two beads and create DNA forks in situ by force manipulation. They then visualized the behavior of single CMG complexes using fluorescence imaging while subjecting the replisome assembly to different reaction conditions by utilizing the laminar flow microfluidics.

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