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Novel imaging-based assay for hERG channel inhibition using iPS-derived Cardiomyocytes

Apr 4, 2019

It has been reported that certain drugs prolong the QT interval through a delayed inhibitory effect on the hERG channel by reducing the density of hERG channels on the plasma membrane after chronic drug exposure. In order to develop a highly predicative assay to detect QT prolongation potential after chronic treatment,we used human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM).In the present study, we would like to introduce a novel cardiotoxicity assay method that utilizes live-cell imaging analysis and present the results of several agents, such as cycloheximide, geldanamycine, tunicamycine, desipramine, breferdine and pentmidine, which affect hERG channel synthesis, trafficking and the glycosylation process.

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