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The Role of Micro-CT in Imaging Breast Cancer Specimens

Bruker Biospin

Jun 17, 2020

The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full...

Bruker´s micro-CT used for some of the World’s First in vivo COVID-19 Imaging Experiments

Bruker Biospin

Jun 9, 2020

Bruker's BioSpin PreClinical Imaging Division reports the use of the Bruker SkyScan 1278 in vivo micro-CT system at the...

A mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection

Spectral Instruments Imaging

Jun 3, 2020

Soft tissue sarcomas pose a significant clinical challenge, with approximately 12,000 new diagnoses and an estimated...

Immunophenotyping Extracellular Vesicles using Amnis CellStream

Luminex

May 29, 2020

Attempts to analyze EVs using traditional PMT- based flow cytometers has been hampered by the limit of detection of...

Jul 9, 2020

Four-week individual caging of male ICR mice alters body composition without change in body mass

MEDIKORS

May 25, 2020

Could individual caging affect the physical composition of outbred mice? To investigate this, dual X-ray absorptiometry...

Detect structural variants at 1% allele fraction: Dive deeper into heterogeneous cancer samples

BioNano Genomics

May 22, 2020

To get a complete picture of highly rearranged cancer genomes in heterogeneous samples, use Bionano genome imaging...

Insulin receptor substrate 1 is a substrate of the Pim protein kinases

Spectral Instruments Imaging

May 18, 2020

The goal of these studies was to identify Pim substrate(s) that could help define the pathway regulated by these...

Jul 9, 2020

Implementation of Micro CT in CAD/CAM dentistry for image processing and soft computing

Bruker Biospin

May 4, 2020

Present radiology devices are playing an important role in clinical dentistry but their area of application islimited...

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Optical advances – the latest developments in Preclinical imaging

Aug 5, 2016

Preclinical in vivo molecular imaging is widely regarded as a key tool within the drug discovery and development pipeline, giving researchers clear visibility of cellular changes at a molecular level. Techniques – or modalities – such as optical, PET and SPECT imaging provide high specificity and wide applicability, as well as the ability to monitor several molecular events and identify key molecular markers. The result is a deeper understanding of disease progression, and the mode of action and pharmacokinetics of potential therapeutics.

If we consider small animal optical imaging systems specifically, these now enable researchers to combine a number of imaging modalities using the same instrument, thereby paving the way for a better understanding of physiological and disease mechanisms in the preclinical setting. For example, one such system provides five imaging modalities as standard, allowing for co-registration of molecular events with access to bioluminescence, multispectral VIS-NIR fluorescence, unique direct radioisotopic imaging, and Cerenkov radiation. A high speed digital X-ray scanner adds to the functional images with morphological features.

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Bruker Biospin

Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.

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