Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
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The draft genome sequence of the Japanese rhinoceros beetle Trypoxylus dichotomus septentrionalis
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The SageHLS instrument was used to size select DNA between 50-80 kb for 10X Genomics Chromium linked read analysis.
Factors Affecting Petri Dish Condensation in Tissue Culture (CU) Chambers
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In this report, we will investigate the effects of infrared lighting, light intensity, stacking, as well as constant...
Visualization of spatial distribution of hemoglobin with various oxygen saturations in small animals
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A fluorescent reporter system for anaerobic thermophiles
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Vizgen webinar: spatial relationships in Developmental Biology
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Validation of an orthotopic non-small cell lung cancer mouse model to use in radiotherapy studies
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IVIM in vivo platform to study efficacy of adoptive and anti-PD- 1- based immunotherapy
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Preclinical cardiac safety assessment using xCELLigence Cardio
Apr 21, 2016
Most of the drugs that have been withdrawn from the market due to cardiotoxicity appear to affect heart function by directly interfering with well-coordinated electrical activity in the heart.The electrical activity of the heart itself results from directional and selective movement of calcium, sodium, and potassium ions across channels in the membrane of cardiomyocytes; this movement couples with the specialized cytoskeleton to produce contraction and the force necessary for the pumping action of the heart. Interfering with this well-orchestrated movement of ions across the cardiomyocyte membrane can lead to electrical arrhythmia that will ultimately affect the excitation/contraction coupling cycle of the heart and may lead to a life-threatening form of ventricular arrhythmia called Torsades de Pointes (TdP).
Related technologies: Real-time, label free cell analysis
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