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Product update: The high pass plus cassette

Apr 9, 2019

High Pass size selection removes smaller DNA fragments from a sheared genomic DNA (or sequencing library) while collecting the remaining larger fragments above a tightly controlled size threshold. This way, larger molecules can be presented to the detector or droplet, and better sequencing performance can be achieved. The High Pass Plus cassette has a stocky separation column, so DNA has a shorter distance to travel. The wider column and increased taper provide higher resolution for a cleaner and more accurate size cut-off. The larger sample wells now allow a maximum load of 10ug (100% up from standard Blue Pippin cassettes). We’ve also increased the size of the elution module and surface area of the filtration membrane, bringing about improved sample recovery and reproducibility.

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Related technologies: Targeted DNA/protein size collection

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Regina Fillerová

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Sage Science

Preparative electrophoresis systems for targeted size selection of biomolecules.

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Targeted Size Selection for Next-Gen Sequencing (90bp – 1.5kb)

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Targeted Size Selection for Next-Gen Sequencing (90bp – 50kb)

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Automated size selection for 24 samples at a time.

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