Accelerate to discover

Homepage>Discover>Protectome analysis: A new selective tool for bacterial vaccine discovery

Back to filter

Oct 22, 2020

Time lapse confocal imaging has been an essential method to investigate the 3D dynamic behaviors of cells in tissue...

Meet the Expert - Brent Barre interview

Oct 21, 2020

Learn what a researcher at the forefront of COVID-19 research has to say about his current research environment.

Easy and accurate cell counting in less than 20 seconds with C100 counter

Oct 16, 2020

Cell counters are tools for counting live and/or dead cells in a culture. Any researcher who works in a cell culture...

Automated fever & hypothermia detection

Oct 14, 2020

As one of the oldest clinical indicators of disease in mammals, temperature is a crucial parameter to monitor,...

Oct 25, 2020

Multi-modal molecular imaging driving pre-clinical research & pharmaceutical development

Oct 6, 2020

Multi-modal molecular imaging at Massachusetts General Hospital – driving pre-clinical research and patient pathways...

Developing tools for multiplex to single EV analysis pipelines

Sep 30, 2020

Extracellular vesicles (EVs) are lipid spheres released from cells. EVs express proteins and contain cargo that pertain...

IncuCyte webinar : clonal heterogeneity promotes metabolite exchange to support pancreatic tumor

Sep 25, 2020

Pancreatic ductaladenocarcinoma (PDA) is the third leading cause of cancer related death in the United States,...

Oct 25, 2020

Why ventilator is so important in the battle against COVID-19?

Sep 21, 2020

The COVID-19 has caused shortages of medical devices in many countries, especially ventilators. Many companies around...

Show all topics (10)

Protectome analysis: A new selective tool for bacterial vaccine discovery

Feb 28, 2018

Several laboratories have been trying to refine the original approach in order to get to the identification of the relevant antigens straight from the genome. Here we report a new bioinformatics tool that moves a first step in this direction. The tool has been developed by identifying structural/functional features recurring in known bacterial protective antigens, the so called “Protectome space,” and using such “protective signatures” for protective antigen discovery. In particular, we applied this new approach to Staphylococcus aureus and Group B Streptococcus and we show that not only already known protective antigens were re-discovered, but also two new protective antigens were identified.

Read more

Scientific paper

Application

Related technologies: Real-time, label free cell analysis

Get more info