Accelerate to discover

Back to filter

Related topics

Centrifugation of suspension cells is a problem!

Curiox

Jul 8, 2020

Do you think that centrifuging cells at 500 x g is not going to cause issues? Moreover, sample prep involving...

IncuCyte webinar: Advances in 3D cell models for cancer biology

Sartorius

Jul 1, 2020

Get answers to your questions on 3D spheroid-based drug discovery, organoid research and working with advanced cell...

Bruker MicroCT systems supporting quality control for refurbished FFP masks

Bruker Biospin

Jun 29, 2020

In the effort to tackle the coronavirus pandemic, Bruker is proud that its instruments are being used to ensure quality...

Advance your Neuro-Oncology applications with IncuCyte

Sartorius

Jun 25, 2020

Neuro-oncology research can benefit from robust translational in vitro models to gain greater understanding of brain...

Jul 8, 2020

MicroCT Applications in Lung research and Immunology

Bruker Biospin

Jun 22, 2020

The ability to monitore and quantitate lung disease in real time is an advantage to using small animal microCT. Also,...

Imaging Extracellular Vescicles with super-resolution microscopy

ONI

Jun 18, 2020

Extracellular vesicles (EVs) play key roles in cell-to-cell communication. EVs can cross biological barriers (such as...

The Role of Micro-CT in Imaging Breast Cancer Specimens

Bruker Biospin

Jun 17, 2020

The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full...

Jul 8, 2020

Bruker´s micro-CT used for some of the World’s First in vivo COVID-19 Imaging Experiments

Bruker Biospin

Jun 9, 2020

Bruker's BioSpin PreClinical Imaging Division reports the use of the Bruker SkyScan 1278 in vivo micro-CT system at the...

Show all topics (10)

Real-time study of platelet formation under sheer-flow with Lumascope

Jun 18, 2018

Platelets are discoids with the size of about 2-3 µm which are responsible for thrombosis and hemostasis. Today platelet transfusion has wide clinical application in blood clotting and wound healing with over 2 million units of platelets transfused every year in the US alone. However, the need for human donors and short shelf life of five days makes the use complicated. Therefore, novel approaches to generate platelets ex vivo are being researched. A promising approach is deriving platelets from megakaryocytes. But generating a large number of platelets with megakaryocyte stimulation has proved difficult. In this research, a sheer-rate bioreactor was used to stimulate the blood flow in the body to encourage the stimulation. Formation of a high number of platelet-like-particles (PLPs) was observed after this stimulation with Lumascope microscope inside of an incubator. Videos of 6 frames per second were generated in five-minute intervals and further analysed. It was shown that introduction of sheer-flow had an almost immediate effect on the PLP generation. With a six-fold increase of PLP production under single flow. This study shows promising results in understanding the PLP formation and creates a possibility of using these condition in creating ex vivo platelets for clinical use. 

Scientific paper
Application

Brand profile

Etaluma

With a focus on portability, ease of use, high-quality imaging and fast frame-rate, Etaluma developed new concept in simple, affordable, and accessible fluorescence microscopy.

Related products

Lumascope 620 offers a larger sensor and 3-color fluorescence for the most powerful microscope offered anywhere at this price

show detail

Blue, green & red fluorescence and walk-away automation

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey