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Simultaneous Measurement of Cardiomyocyte Contractility and Electrophysiology

Sep 29, 2015

The xCELLigence RTCA CardioECR System allows for comprehensive evaluation of processes involved in cardiomyocyte excitation-contraction coupling. The included software package is specifically designed to identify and measure adverse compound action on integrated ion channel activity, contractility and longer term viability and thus provides a highly predictive assay system for cardiac risk assessment.

 

The principle of detection for the xCELLigence RTCA CardioECR System is based on impedance and field potential measurements. The interdigitated gold impedance electrodes are interspersed with two field potential electrodes. These electrodes are specially designed for simultaneous measurement of field potential and contractility within each well of the microtiter plate.

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Related technologies: Real-time, label free cell analysis

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Riccardo Pasculli

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

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