Spectral Instruments Imaging manufactures instruments for preclinical optical (bioluminescent, fluorescent) and X-ray imaging.
Automated microscopy and image analysis
Real-time, label free cell analysis
Nano and micro particle analysis
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Nov 30, 2021
Microfluidics have revolutionized...
Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer
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Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...
Nov 10, 2021
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Discover the advanced Detector Technology in Agilent NovoCyte flow cytometers
Nov 8, 2021
This technical overview describes advancements in detector technology, and highlights examples where optimal signal...
Oct 20, 2021
Ionizing radiation approaches are effective but use of radioactive radioisotopic elements have become difficult to...
Duke uses XRAD 225 CX to test radiosensitivity hypothesis
Oct 18, 2021
Image guided radiotherapy in a preclinical setting couldn’t be more useful than the treatment of brain tumors, where...
Curiox webinar: Laminar Wash enables single-cell multiomics and cell hashing
Oct 11, 2021
Professor Mats Bemark’s lab at the University of Gothenburg in Sweden studies how the immune system responds to...
Falling in love with Magnetic resonance
Oct 4, 2021
Magnetic Resonance (MR) is more than just analytical science, it is unique, it is a passion that won’t let you go
Squaraine fluorophore as a NIR-fluorescent probe for the in vivo detection of diagnostic enzymes
Nov 19, 2018
Squaraine dyes have excellent photostability with intensive absorption and strong fluorescence in the near-infrared (NIR) region. However, they display a strong tendency to aggregate in aqueous media because of their poor water solubility, often causing fluorescence quenching that severely limits their in vivo applications, especially for detecting or imaging diagnostic enzymes. In this work, an oligo(ethylene glycol)-functionalized squaraine fluorophore has been developed as an NIR-fluorescent probe that can detect and image the activities of a diagnostic enzyme (leucine aminopeptidase) both in vitro and in vivo. The probe shows near-infrared absorption and emission, a low detection limit (0.61 ng/mL), relatively good aqueous solubility, high selectivity, and little toxicity. In addition, the probe herein was successfully used to track endogenous leucine aminopeptidase both in vitro and in vivo with a nude-mouse model.
Related technologies: Fluorescence, luminescence, X-ray, radiographic imaging
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