Spectral Instruments Imaging manufactures instruments for preclinical optical (bioluminescent, fluorescent) and X-ray imaging.
Automated microscopy and image analysis
Real-time, label free cell analysis
Nano and micro particle analysis
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Standardize tumor sample preparation and reduce background with Curiox laminar wash system
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Laminar Wash technology offers a gentle alternative that can improve yield and data quality, particularly of rare cell...
Developing a 43 color panel on Cytek Aurora using Laminar Wash for sample prep
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Successfully executing a 43 color panel is a technically demanding task. One that is made more difficult when there are...
Intoducing spheroOne: Automated sorting and isolation of single spheroids and organoids
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spheroONE is an innovative single large-particle sorter and dispenser which revolutionizes 3D cellular models handling....
Outstanding post-sort sample recovery on the WOLF Cell Sorter
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The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...
Incucyte AI module: Advanced Label-Free Classification Analysis
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Monitor adherent cell morphology changes objectively to determine live/dead cell counts or classify cells based on...
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters
Jun 3, 2022
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...
An experimental strategy for preparing circular ssDNA virus genomes for next-generation sequencing
Jun 1, 2022
Recent article from February 2022 shoes how size selection improved viral read mapping by over 90% for begomoviruses.
Intoducing cellenONE: The revolutionary Single Cell isolator
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Squaraine fluorophore as a NIR-fluorescent probe for the in vivo detection of diagnostic enzymes
Nov 19, 2018
Squaraine dyes have excellent photostability with intensive absorption and strong fluorescence in the near-infrared (NIR) region. However, they display a strong tendency to aggregate in aqueous media because of their poor water solubility, often causing fluorescence quenching that severely limits their in vivo applications, especially for detecting or imaging diagnostic enzymes. In this work, an oligo(ethylene glycol)-functionalized squaraine fluorophore has been developed as an NIR-fluorescent probe that can detect and image the activities of a diagnostic enzyme (leucine aminopeptidase) both in vitro and in vivo. The probe shows near-infrared absorption and emission, a low detection limit (0.61 ng/mL), relatively good aqueous solubility, high selectivity, and little toxicity. In addition, the probe herein was successfully used to track endogenous leucine aminopeptidase both in vitro and in vivo with a nude-mouse model.
Related technologies: Fluorescence, luminescence, X-ray, radiographic imaging
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