Accelerate to discover

Back to filter

Related topics

xCELLigence system: rapid and sensitive, ideal for infectious viral assays.

Acea Biosciences

Mar 30, 2020

As the public health threat from COVID-19 and future emergent viruses continue to persist, the rapid, sensitive, and...

Genotype-targeted local therapy of glioma

Spectral Instruments Imaging

Mar 26, 2020

Lower-grade gliomas are often characterized by mutations in metabolism-related genes isocitrate dehydrogenase 1 (IDH1)...

Cytek spectral cytometers: 21 color panels with just 2 lasers

Cytek Biosciences

Mar 23, 2020

Until recently, developing multicolor fluorescence-based flow cytometry assays on a two laser system has been limited...

Cancer cells resist mechanical destruction in the circulation via RhoA-myosin II axis

Spectral Instruments Imaging

Mar 20, 2020

Tumors may generate millions of Circulating tumor cells per day, but seminal work in cancer biology has established the...

Mar 31, 2020

IncuCyte live cell analysis system for 3D Organoids discovery

Sartorius

Mar 18, 2020

Live-Cell Analysis has revolutionized numerous studies, with a wide selection of applications namely 3D Tumour Spheroid...

Webinar recording: Ex vivo microangioCT, advances in microvascular imaging

Bruker Biospin

Mar 16, 2020

A new technique called microangioCT imaging is being used with a novel polymerizing contrast agent that enables 3D...

Single Cell Sequencing sample preparation without centrifugation

Curiox

Mar 10, 2020

Single-cell genomics is rapidly growing. Nature Methods named multimodal omics the method of the year for 2019. And as...

Mar 31, 2020

Comparing image quality in Phase Contrast X-Ray Tomography

Bruker Biospin

Feb 28, 2020

How to evaluate and compare image quality from different submicrometer CT scans? A simple yet clever test phantom is...

Show all topics (10)

Squaraine fluorophore as a NIR-fluorescent probe for the in vivo detection of diagnostic enzymes

Nov 19, 2018

Squaraine dyes have excellent photostability with intensive absorption and strong fluorescence in the near-infrared (NIR) region. However, they display a strong tendency to aggregate in aqueous media because of their poor water solubility, often causing fluorescence quenching that severely limits their in vivo applications, especially for detecting or imaging diagnostic enzymes. In this work, an oligo(ethylene glycol)-functionalized squaraine fluorophore has been developed as an NIR-fluorescent probe that can detect and image the activities of a diagnostic enzyme (leucine aminopeptidase) both in vitro and in vivo. The probe shows near-infrared absorption and emission, a low detection limit (0.61 ng/mL), relatively good aqueous solubility, high selectivity, and little toxicity. In addition, the probe herein was successfully used to track endogenous leucine aminopeptidase both in vitro and in vivo with a nude-mouse model.

Do you want to learn more? Read this interesting article!

Scientific paper
Application

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

Spectral Instruments Imaging

Spectral Instruments Imaging manufactures instruments for preclinical optical (bioluminescent, fluorescent) and X-ray imaging.

Related products

System for individual researchers and smaller specialist teams to conduct optical imaging studies in disease model progression, response to therapy, and cell migration in-vivo.

show detail

The Ami HT and Ami HTX (includes X-Ray imaging) optical imaging systems establish a new, high throughput benchmark for in vivo imaging suitable for specialist researchers and small teams.

show detail

The Lago and X‐Ray capable Lago X optical imaging systems provide a powerful and flexible in-vivo imaging capability suitable for imaging cores, specialist researchers and small teams, delivering an unmatched 10 mouse capacity across BLI, FLI and X‐Ray.

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey