Accelerate to discover

Back to filter

Related topics

Development of superparamagnetic nanoparticles as an efficient contrast agent for multimodal imaging

Bruker Biospin

Jan 16, 2020

Gadolinium‐based contrast agents are used to provide diagnostic information in clinical magnetic resonance...

IncuCyte live-cell analysis system for live-cell visualization of neuronal activity

Sartorius

Jan 13, 2020

A major impediment to studying diseases affecting the human nervous system is the ability to monitor, analyze, and...

Latest updates to Bionano Access and Bionano Solve

BioNano Genomics

Jan 8, 2020

Bionano Access v1.5 and Bionano Solve v3.5 are the latest updates to Bionano visualization software and analysis tools....

The importance of titrating Viability dyes on the Aurora Spectral Cytometer

Cytek Biosciences

Jan 2, 2020

What is the best way to decide when your viability is titrated properly? Unlike titrating antibodies how to determine...

Jan 18, 2020

New analysis open modules expand capabilities of Guava Muse flow cytometer

Luminex

Dec 30, 2019

Sophisticated cell analysis doesn’t have to be complicated or costly. With the Guava Muse cell analyzer, you can now...

High molecular weight DNA from bone marrow aspirates samples in 4 hrs

BioNano Genomics

Dec 23, 2019

With Bionano Prep SP BMA DNA Isolation kit, transform the way you are isolating UHMW DNA from this complex sample type...

Excellent resolution of small particles using NovoCyte Quanteon flow cytometer

Acea Biosciences

Dec 18, 2019

The importance of cell-derived EVs has been recognized in multiple biological processes, and is a topic of increasing...

Jan 18, 2020

Cutting-edge analysis of Extracellular Microparticles using ImageStream Imaging Flow Cytometry

Amnis

Dec 16, 2019

Interest in extracellular vesicle biology has exploded in the past decade, since these microstructures seem endowed...

Show all topics (10)

Squaraine fluorophore as a NIR-fluorescent probe for the in vivo detection of diagnostic enzymes

Nov 19, 2018

Squaraine dyes have excellent photostability with intensive absorption and strong fluorescence in the near-infrared (NIR) region. However, they display a strong tendency to aggregate in aqueous media because of their poor water solubility, often causing fluorescence quenching that severely limits their in vivo applications, especially for detecting or imaging diagnostic enzymes. In this work, an oligo(ethylene glycol)-functionalized squaraine fluorophore has been developed as an NIR-fluorescent probe that can detect and image the activities of a diagnostic enzyme (leucine aminopeptidase) both in vitro and in vivo. The probe shows near-infrared absorption and emission, a low detection limit (0.61 ng/mL), relatively good aqueous solubility, high selectivity, and little toxicity. In addition, the probe herein was successfully used to track endogenous leucine aminopeptidase both in vitro and in vivo with a nude-mouse model.

Do you want to learn more? Read this interesting article!

Scientific paper
Application

Get more info

Miroslav Vecheta

Support specialist

Miroslav

Vecheta

+420 255 700 886

Send Message

Brand profile

Spectral Instruments Imaging

Spectral Instruments Imaging manufactures instruments for preclinical optical (bioluminescent, fluorescent) and X-ray imaging.

Related products

System for individual researchers and smaller specialist teams to conduct optical imaging studies in disease model progression, response to therapy, and cell migration in-vivo.

show detail

The Ami HT and Ami HTX (includes X-Ray imaging) optical imaging systems establish a new, high throughput benchmark for in vivo imaging suitable for specialist researchers and small teams.

show detail

The Lago and X‐Ray capable Lago X optical imaging systems provide a powerful and flexible in-vivo imaging capability suitable for imaging cores, specialist researchers and small teams, delivering an unmatched 10 mouse capacity across BLI, FLI and X‐Ray.

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey