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Imaging Performance of a multimodal module to enhance preclinical irradiator capabilities

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Upgrading an existing irradiator with such a multi-modal imaging device is a reasonable investment in laboratories...

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The goal of breast cancer surgery is to remove all of the cancer with a minimum of normal tissue, but absence of full...

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Four-week individual caging of male ICR mice alters body composition without change in body mass

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Could individual caging affect the physical composition of outbred mice? To investigate this, dual X-ray absorptiometry...

Detect structural variants at 1% allele fraction: Dive deeper into heterogeneous cancer samples

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To get a complete picture of highly rearranged cancer genomes in heterogeneous samples, use Bionano genome imaging...

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Insulin receptor substrate 1 is a substrate of the Pim protein kinases

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The goal of these studies was to identify Pim substrate(s) that could help define the pathway regulated by these...

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Use of the real time xCelligence system for purposes of medical microbiology

Apr 21, 2016

Celligence impedance-measuring instrument is one of a few commercially available systems of such type. The aim of this work was to estimate xCELLigence suitability for the microbiological tests, including measurement of morphological changes in eukaryotic cells as a result of bacterial toxin activity, measurement of bacterial biofilm formation and impact of antiseptics on the biofilm structure. To test the infuence of bacterial enterotoxin on eukaryotic cell lines, Chinese Hamster Ovary (CHO) cell line and reference strain Escherichia coli ATTC 35401 were used. To investigate instrument ability to measure biofilm formation and impact of antiseptics on its development, Staphylococcus aureus ATTC6538 reference strain was used. The data generated during the experiments indicate excellent ability of xCelligence instrument to detect cytopathic effect caused by bacterial LT endotoxin and to detect staphylococcal biofilm formation.  xCelligence instrument can be used for real-time monitoring of morphological changes in CHO cells treated with bacterial LT enterotoxin and for real-time measurement of staphylococcal biofilm formation in vitro.

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Related technologies: Real-time, label free cell analysis

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Located inside a tissue culture incubator, the RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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