Accelerate to discover

Back to filter

Related topics

Webinar recording: Deep dive into Spatial Biology with MERSCOPE Ultra Platform

Vizgen

Aug 16, 2024

We invite you to learn more about MERSCOPE Ultra Platform. Webinar featuring Rob Mathis (Global Instrument Product...

Webinar recording: Exploring Platelet Adhesion and Aggregation Under Physiological Shear Flow

Cell Microsystems

Aug 14, 2024

In this webinar, Dr. Mohammad Ekhlak of Banaras Hindu University will share data and insights from the Center for...

Celloger Pro live-cell analyzer: miniaturized and powerful tool for Spheroids and Organoids research

Curiosis

Jul 31, 2024

Celloger live-cell analyzers, image and analyze your cells in real-time, inside your incubator. With its exceptional...

Automatic, Real Time Acquisition of Bioluminescent Kinetic Curves

Spectral Instruments Imaging

Jun 27, 2024

Watch this pre-recorded webinar with Dr. Andrew Van Praagh to learn how our new Aura software feature —Kinetics—...

Oct 4, 2024

Hypoxia in the Tumor Immune Microenvironment (TIME)

Bruker Biospin

Jun 6, 2024

Thursday, 11 July 2024, 16:00 CET | 10:00 EST
Zaver M. Bhujwalla, PhD...

Exosome-Mediated Delivery of Small Molecules, RNA & DNA for Development of Novel Cancer Therapeutics

Spectral Instruments Imaging

Jun 3, 2024

Disha Moholkar of University of Louisville's Gupta Lab
Tuesday, June 11, 2024, 6:30 PM
...

Have you missed any recent Cytek webinars? Watch webinars and product tutorial videos at any time

Cytek Biosciences

Apr 23, 2024

Have you missed any recent Cytek webinars? Watch webinars and product tutorial videos at any time at Cytek website....

Oct 4, 2024

Discover the Celloger live-cell analyzers : miniaturized and powerful tools for every Biologist

Curiosis

Apr 5, 2024

Celloger live-cell analyzers, image and analyze your cells in real-time, inside your incubator. With its exceptional...

Show all topics (10)

Webinar recording : BioFlux, the gold standard for Platelet Biology and Thrombosis research

Jul 29, 2024

The BioFlux system give you the ability to introduce physiological shear flow to your research and drug discovery experiments, effectively emulating in vivo conditions for Platelet Biology and Vascular Pharmacology studies.

Thrombosis, the underlying cause of major fatal conditions like ischemic stroke and myocardial infarction, poses a challenge for treatment. Tissue plasminogen activator (tPA), the primary nonsurgical remedy, faces limitations due to high hemorrhagic risk and a low success rate in clearing thrombi. Neutrophil extracellular traps (NETs), protein-rich structures in blood clots, contribute to tPA resistance. In our microfluidic models of NET-rich clots, we discovered a core-shell structure, with the shell showing significant tPA resistance. The incorporation of DNAse, an enzyme degrading NETs, restored clot tPA susceptibility. Based on these findings, we proposed a localized co-delivery strategy using a liposomal drug delivery platform. Two types of nanoparticles were engineered: tPA-loaded nanoparticles (tPA-NP) and DNAse-loaded nanoparticles (DNAse-NP). Thrombin and neutrophil elastase-cleavable substrates ensured controlled release upon exposure to clot-specific enzymes. tPA-NP demonstrated fibrinolytic potential comparable to solvated tPA, while DNAse-NP exhibited NET-lytic activity. Alone, neither fully addressed clot lysis in functional assays. However, the combined delivery of DNAse-NP and tPA-NP achieved complete clot dissolution within 12 minutes. This approach presents a tunable, modular, and efficacious drug delivery platform for overcoming thrombosis resistant to traditional therapies.

Watch the webinar now

Video
Webinar

Related technologies: Cell interaction studies

Get more info

Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

Cell Microsystems

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Cell Microsystems turn power of benchtop cellular analysis with advanced tools to automate complex assays.

Related products

System that offers a fully-integrated solution for automated, high throughput shear flow assays

show detail

Core control system, integrated to any inverted microscope to introduce flow to your research

show detail

Affordable and high throughput platform for shear flow assays

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey