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Low-dose imaging in a new preclinical total-body PET/CT scanner

Bruker Biospin

Jun 12, 2019

Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing...

Fluxion Biosciences and National Cancer Institute cooperate to validate IsoFlux for sequencing

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Scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates...

Join the AVANCE Track & Keep your MRI on Track

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Jun 4, 2019

Your research depends on the scientific advances that you make with your MRI instrument. Take your instrument and your...

Jun 18, 2019

A novel method for isolating high-quality UHMW DNA from animal and human tissues

BioNano Genomics

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New isolation protocol for isolating high-quality UHMW DNA from 10 mg of freshly frozen or liquid-preserved animal and...

ParaVision 7 software

Bruker Biospin

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The preclinical MRI software ParaVision 7 delivers unsurpassed image quality and enhanced productivity for both routine...

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Sage Science

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The CATCH process  provides researchers with the most direct access to genes for study. Target regions are defined with...

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Introducing the first EV isolation column capable of running 100 mL samples.

IZON

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As the EV field continues to grow and advance, so has the need for scalability in EV isolation. Izon is addressing this...

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xCELLigence cancer immunotherapy: NK cell-mediated cytolysis

May 4, 2016

ACEA Biosciences developed a label-free assay format that allows dynamic monitoring of NK cell-mediated cytolysis. The assay uses impedancebased technology (RT-CES)4,5. This system is the predecessor of the new xCELLigence System. The attachment and interaction of adherent cells with wells on a 96X E-Plate leads to impedance changes, which correlate with cell number, size and shape. In contrast, addition of suspended cells to the wells results in undetectable changes due to non-existent or weak interaction with the electrodes. Therefore, NK cell-mediated cytolytic effects on the cancer cell monolayer can be quantitatively and dynamically monitored on the sensor plate without labeling the target cells.

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Related technologies: Real-time, label free cell analysis

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Riccardo Pasculli

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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