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Introducing Celloger Mini: Automated and compact Live cell imaging inside your incubator

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Jul 23, 2021

Celloger Mini is an automated live cell imaging system based on bright-field microscopy with fully motorized stages. 

High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma

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Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence, fluorescence and X-Ray for in vivo...

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Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles

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Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual...

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Microvascular injury in mild traumatic brain injury accelerates alzheimer-like pathogenesis in mice

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Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease....

Quantitative two-photon microscopy imaging analysis of human skin

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Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively....

Elevated NSD3 histone methylation activity drives squamous cell lung cancer

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This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in LUSC, and suggests that...

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A subset of cytotoxic effector memory T cells enhances CAR T cell efficacy in a model of pancreatic

Tonbo Biosciences

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Tonbo Biosciences flow cytometry reagents & antibodies are manufactured with the highest quality and precision and...

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xCELLigence cancer immunotherapy: NK cell-mediated cytolysis

May 4, 2016

ACEA Biosciences developed a label-free assay format that allows dynamic monitoring of NK cell-mediated cytolysis. The assay uses impedancebased technology (RT-CES)4,5. This system is the predecessor of the new xCELLigence System. The attachment and interaction of adherent cells with wells on a 96X E-Plate leads to impedance changes, which correlate with cell number, size and shape. In contrast, addition of suspended cells to the wells results in undetectable changes due to non-existent or weak interaction with the electrodes. Therefore, NK cell-mediated cytolytic effects on the cancer cell monolayer can be quantitatively and dynamically monitored on the sensor plate without labeling the target cells.

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Related technologies: Real-time, label free cell analysis

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Riccardo Pasculli

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Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Located inside a tissue culture incubator, the RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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