The IsoFlux System enables somatic variant detection from circulating tumor cells (CTCs) obtained from a routine blood draw using the latest advances in Next-Generation Sequencing (NGS). The system enriches circulating tumor cells, or other rare circulating cells, from peripheral blood and prepares them for molecular analysis, including NGS, qPCR, FISH, and immunofluorescence. The resulting samples have the required tumor DNA content and purity to be used with the leading NGS content panels, ranging from 50 to 400 genes and thousands of variants.
The IsoFlux system is about more than just capturing and counting circulating tumor cells. It is the critical link that allows genomic information from tumor cells to be obtained from a routine blood draw. The IsoFlux system has become the premier platform for molecular profiling of CTCs:
- High sensitivity of CTCs across many tumor types
- Tumor cell purity above 10% to meet the demands of NGS
- Simple to operate, benchtop design
- Consumable kits and protocols for NGS, qPCR, and immunofluorescence microscopy
