CLL MASTR Plus - Multiplicom

Somatic mutations in 9 genes associated with Chronic Lymphocytic Leukemia (CLL)

The CLL MASTR Plus is a molecular assay for the identification of both SNVs and CNAs in 9 selected genes in individuals with indication of Chronic lymphocytic leukemia (CLL). Multiplicom’s CLL MASTR Plus assay is provided as a ready-to-use kit that offers robust performance with minimum hands-on time. 

Chronic lymphocytic leukemia (CLL) is a B-cell lymphoproliferative disorder, involving peripheral blood, bone marrow and lymphoid organs. CLL represents the most common form of leukemia in adults in Western Countries. The clinical course is extremely heterogeneous, with survival ranging from months to decades. Common clinical signs include swelling of lymph nodes, liver and spleen, as well as unintentional weight loss, severe fatigue, fever, night sweats, and frequent infections.

FISH karyotyping is commonly used for risk stratification of CLL patients. Cytogenetic lesions however do not entirely explain the clinical heterogeneity of CLL. Recently, the understanding of the complexity of the molecular genetics of CLL has broadened profoundly and novel common gene mutations potentially involved in the disease were identified. Markers that might be relevant for refined prognostic stratification and/or clinical management of CLL patients, include variants in TP53, BIRC3, NOTCH1 and SF3B1 and copy number alterations, such as del11q22-q23 and del17p13.

Current methods, such as Sanger-based sequencing and FASAY, are time-consuming, labor-intensive and expensive. Identification of somatic mutations with the CLL MASTR Plus provides a faster and cost-effective approach.

Note: This assay is to be used for research use only.

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Petra Kupková

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