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SOMATIC 1 MASTR Plus Dx - Multiplicom

A flexible NRAS-KRAS-BRAF panel

SOMATIC 1 MASTR™ Plus Dx is a CE-IVD labeled molecular diagnostic assay for the identification of mutations in NRAS, KRAS and BRAF genes in cancer patients. The flexible kit either allows a test for the most frequent mutations (plex 1 only) or for the entire coding region of NRASKRAS and BRAF.

The analysis of mutations in NRASKRAS and BRAF genes is important to decide the treatment options for patients with cancer. Namely, analysis of mutations in NRASKRAS and BRAF helps determine the treatment options for patients when EGFR inhibitor or BRAF inhibitor treatment is considered. Mutations in these genes have been observed in a variety of cancers such as pancreas, thyroid follicular and colorectal cancers, adenocarcinoma, myeloid disorders and melanoma.

The frequency rate and prevalence of these oncogenic mutations in NRASKRAS and BRAF differs between different types of cancer. Therefore, the SOMATIC 1 MASTR Plus Dx has been designed to allow a flexible selection with either only mutation analysis of the hotspot mutations or of the full coding region of KRAS and NRAS, and BRAF gene. The hotspots are analyzed in only one multiplex PCR reaction (i.e. plex 1) and combining all three plexes in parallel ensures full coverage of all three genes. 

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http://www.multiplicom.com/product/somatic-1-mastr-plus-dx
Petra Kupková

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Petra

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