"We realize the power of adding Next-Generation Mapping from the Irys System to our research focused on genetic abnormalities in hematologic and lymphoid malignancies."

Dr. Eva Kriegová

Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic

Irys - BioNano Genomics

See Whole Genomes More Completely Than Ever

Acquire high-resolution, multi-color images and conduct single-molecule analysis of long DNA molecules with the automated, benchtop Irys instrument. Simply load your sample, set your run on the touch-screen controls, and walk away as the system automatically flows DNA into the massively parallel array of NanoChannels on an IrysChip, collecting images and extracting data. By repeatedly cycling the same DNA sample through the same flowcell, Irys can process several gigabases of DNA per hour.

Unamplified, native-state DNA molecules, each up to a megabase long, can be loaded into the IrysChip’s NanoChannels. The Irys uses laser excitation to illuminate fluorescently labeled DNA in the NanoChannels of the chip. The DNA can be labeled using a wide variety of methods, including IrysPrep reagents or user-defined methods. An onboard CCD camera, coupled with proprietary auto-focusing mechanism and control software, rapidly scans the chip. Molecules are uniformly stretched and optically separated in NanoChannels, presenting high-resolution imaging of single molecules without extreme conditions and optics that make other platforms impractical and cost-prohibitive.

The Irys’ control software makes processing samples effortless. Simply set up a run on the intuitive touchscreen and let the built-in software do the rest. The software automatically generates primary data for use in a number of applications. During a run, quality control metrics are constantly monitored and displayed on the screen, keeping you informed of the run’s progress and success.

Key Features:

  • Fully automated cycling of DNA into chip and imaging
  • Intuitive touchscreen interface
  • 3 laser lines for simultaneous labeling of multiple events
  • High-resolution optics with proprietary Auto-Focus system
  • Automatic image export and detection

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gEVAL- A Genome Evaluation Browser for Improving Genome Assemblies Looking for structural variations with IRYS from BioNano Genomics De novo sequence assembly using nanochannel arrays from BioNano Genomics Tina Graves webinar - challenges faced in human whole genome assembly BioNano Genomics launches enhanced genome mapping coverage features with new software tools Achieving high-quality de novo human genome assemblies with Irys System from BioNano Genomics Genome-wide structural variation detection by genome mapping on nanochannel arrays Extensive sequencing of seven human genomes to characterize benchmark reference materials Genome mapping in plant comparative genomics The amaranth genome: Genome, transcriptome, and physical map assembly Structural variation analysis within the Arabidopsis 1,001 epigenomes project De novo assembly and phasing of a Korean human genome BioNano optical maps help solve the mystery of the sex chromosomes in garden asparagus Applications of Bionano Next-Generation Mapping (NGM) method to cancer patients–NGS is not enough Introducing Saphyr from BioNano Genomics Rapid automated large structural variation detection in a diploid genome by next-generation mapping Next generation mapping reveals novel large genomic rearrangements in prostate cancer De novo reference assembly of the domestic goat genome Next generation karyotyping: detecting cancer-associated structural variants using optical maps Bionano Genomics’ next-generation mapping identifies large structural variants in cancer Sequencing and de novo assembly of a near complete indica rice genome A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci Whole genome optical mapping reveals multiple fusion events chained by novel sequences in cancer Linked-read sequencing combined with optical mapping produce a high quality mammalian genome Next-generation mapping identifies large structural variants in plant and animal genomes Charting the dark matter of cancer genomes Multiple hybrid de novo genome assembly of finger millet, an orphan allotetraploid crop Launching Bionano U On the origin of replication by means of Bionano mapping Genome sequence of the progenitor of the wheat D genome Aegilops tauschii BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients How to build the largest genome ever, in 3 easy steps From thousands of SVS to a handful of candidate genes Optical methylation mapping made simple Solved with Bionano: The Swedish mystery of the missing reference sequence Single-molecule optical mapping enables accurate molecular diagnosis of FSHD Genoox, Bionano collaborate to enhance the detection of pathogenic SVs New technologies to uncover the molecular basis of disorders of sex development Great ape genomes laid bare New technologies to uncover the molecular basis of disorders of sex development Bionano Genomics news presented at AGBT 2019 Webinar recording: Detecting cancer-associated structural variants using Bionano optical maps A novel method for isolating high-quality UHMW DNA from animal and human tissues Bionano introduce new SP blood and cell culture DNA isolation kit Software Update: Bionano releases a new pipeline for low Aalelic fraction SVs Next-generation cytogenetics is here Webinar recording - Highly sensitive structural variant detection for medical genetics Bionano ICS software upgrade: 2600 Gbp with new instrument control software for Bionano Saphyr High molecular weight DNA from bone marrow aspirates samples in 4 hrs Latest updates to Bionano Access and Bionano Solve Bionano webinar recording : EnFocus FSHD analysis Travel grant ALERT! Submit ESHG abstracts today Webinar recording: Isolating ultra-high molecular weight (UHMW) DNA for genome analysis Detect structural variants at 1% allele fraction: Dive deeper into heterogeneous cancer samples Saphyr identifies all variants detected by the standard of care in cytogenetics
Regina Fillerová

Field application specialist



+420 731 127 718

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