Saphyr - BioNano Genomics

Bionano’s third-generation optical mapping solution

Saphyr features enhanced optics with adaptive loading of DNA utilizing machine learning. The Saphyr instrument and high-capacity Saphyr chip combine to deliver genome maps at the speed and scale your research demands.

  • Long molecules from 100,000 bp to megabase pairs
  • Guaranteed 640 Gbp throughput per Saphyr chip per day for human samples for deep structural variant discovery (320 Gbp per flowcell of molecules larger than 150 kbp)
  • Sample to structural variation call or genome scaffolding in as little as 5 days

Automation features and intelligent sample preparation simplify the proces. Requires less than 3 minutes hands-on instrument time per chip.

Generate high-resolution physical genome maps with greater speed and coverage at a lower cost. Saphyr can run most genomes in a single flowcell, in just one day. With Saphyr chip’s dual-flowcell design, you have the power to generate two independent maps from one sample, with two enzymes, and combine the data.


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Introducing Saphyr from BioNano Genomics Rapid automated large structural variation detection in a diploid genome by next-generation mapping Next generation mapping reveals novel large genomic rearrangements in prostate cancer De novo reference assembly of the domestic goat genome Next generation karyotyping: detecting cancer-associated structural variants using optical maps Bionano Genomics’ next-generation mapping identifies large structural variants in cancer Sequencing and de novo assembly of a near complete indica rice genome A reference genome for Nicotiana tabacum enables map-based cloning of homeologous loci Whole genome optical mapping reveals multiple fusion events chained by novel sequences in cancer Linked-read sequencing combined with optical mapping produce a high quality mammalian genome Next-generation mapping identifies large structural variants in plant and animal genomes Charting the dark matter of cancer genomes Multiple hybrid de novo genome assembly of finger millet, an orphan allotetraploid crop Launching Bionano U On the origin of replication by means of Bionano mapping Genome sequence of the progenitor of the wheat D genome Aegilops tauschii BioNano mapping outperforms existing clinical tests in Duchenne´s muscular dystrophy patients How to build the largest genome ever, in 3 easy steps From thousands of SVS to a handful of candidate genes Direct label and stain chemistry is finally here Optical methylation mapping made simple Solved with Bionano: The Swedish mystery of the missing reference sequence Single-molecule optical mapping enables accurate molecular diagnosis of FSHD Genoox, Bionano collaborate to enhance the detection of pathogenic SVs New technologies to uncover the molecular basis of disorders of sex development Great ape genomes laid bare New technologies to uncover the molecular basis of disorders of sex development Bionano Genomics news presented at AGBT 2019 Webinar recording: Detecting cancer-associated structural variants using Bionano optical maps A novel method for isolating high-quality UHMW DNA from animal and human tissues Bionano introduce new SP blood and cell culture DNA isolation kit Software Update: Bionano releases a new pipeline for low Aalelic fraction SVs Next-generation cytogenetics is here Webinar recording - Highly sensitive structural variant detection for medical genetics Bionano ICS software upgrade: 2600 Gbp with new instrument control software for Bionano Saphyr High molecular weight DNA from bone marrow aspirates samples in 4 hrs Latest updates to Bionano Access and Bionano Solve Bionano webinar recording : EnFocus FSHD analysis Travel grant ALERT! Submit ESHG abstracts today Webinar recording: Isolating ultra-high molecular weight (UHMW) DNA for genome analysis Detect structural variants at 1% allele fraction: Dive deeper into heterogeneous cancer samples Saphyr identifies all variants detected by the standard of care in cytogenetics
Regina Fillerová

Field application specialist



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