Accelerate to discover

Back to filter

Related topics

High-frequency Ultrasound System For Preclinical Imaging

S-Sharp

May 13, 2024

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

“Range+T “ for Tight Sizing of HMW Libraries

Sage Science

May 10, 2024

We decided to do a deep dive into Range+T to get a better handle the method, and to develop best practices for using...

April 2024 publication revealing benefits of using intravital microscopy in trascriptomics studies

IVIM Technology

May 8, 2024

Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded...

Minimal information for studies of extracellular vesicles (MISEV2023)

IZON

May 7, 2024

MISEV2023 is intended to aid any and all EV researchers: from those just starting their EV journey to more established...

May 19, 2024

Omics Studies of Tumor Cells under Microgravity Conditions

CelVivo

May 6, 2024

It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...

Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

Applied Cells

Apr 25, 2024

The MARS® Bar Magnetic Separation Platform is a closed and automated isolation for cell therapy development and...

Spatial and temporal profiling of the complement system uncovered novel functions of the alternative

Vizgen

Apr 24, 2024

Mounting evidence implicated the classical complement pathway (CP) in normal brain development, and the pathogenesis of...

May 19, 2024

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

Precision X-Ray

Apr 4, 2024

Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...

Show all topics (10)

A microthrombus-driven fixed-point cleaved nanosystem for preventing post-thrombolysis recurrence

Apr 3, 2024

Therefore, in this study, a novel therapeutic strategy targeting thrombus formation is proposed by utilizing CREKA-modified and functionalized liposomes as carriers, aiming to enhance patient prognosis and treatment outcomes (Scheme 1). Firstly, surface modification of nanoparticles facilitates targeted drug delivery to activated platelets, thereby improving thrombolysis effectiveness and reducing side effects. Secondly, by utilizing iron chelators as ferroptosis inhibitors to regulate ferritin and transferrin expression and function, intracellular free iron levels can be controlled, diminishing the accumulation of intracellular iron ions and alleviating oxidative stress responses, thereby influencing the equilibrium of the thrombus microenvironment. Of particular significance, excessive ROS plays a crucial role in thrombus formation. Hence, ROS scavenging is also pivotal for enhancing thrombus treatment efficacy. Fer-1, a compound capable of clearing ROS and lowering oxidative stress levels, can be employed to treat ischemia-reperfusion injury [40,41]. Loading Fer-1 into liposomes exploits their characteristics to achieve site-specific release at the thrombus site, which further improves the thrombus microenvironment and ischemia-reperfusion injury, resulting in a triple-effect of treatment, prognosis enhancement, and thrombus microenvironment regulation.


Read entire publication 

Scientific paper
Application

Related technologies: IntraVital Microscopy

Get more info

Irina Cojocaru

Sales manager

Irina

Cojocaru

+40 749 952 785

Send Message

Brand profile

IVIM Technology

IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up living tissue in vivo.

Related products

IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up living tissue in vivo

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey