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New technologies to uncover the molecular basis of disorders of sex development

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Newer approaches, such as whole-genome sequencing and whole-genome mapping have the potential to identify novel...

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3R Compliant drug development studies

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In preclinical imaging, magnetic resonance imaging (MRI) can be an attractive alternative to researchers who have...

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A multimodal imaging approach for longitudinal evaluation of bladder tumor

Oct 21, 2016

Bladder cancer is the fourth most common malignancy amongst men in Western industrialized countries with an initial response rate of 70% for the non-muscle invasive type, and improving therapy efficacy is highly needed. For this, an appropriate, reliable animal model is essential to gain insight into mechanisms of tumor growth for use in response monitoring of (new) agents. Several animal models have been described in previous studies, but so far success has been hampered due to the absence of imaging methods to follow tumor growth non-invasively over time. Recent developments of multimodal imaging methods for use in animal research have substantially strengthened these options of in vivo visualization of tumor growth. In the present study, a multimodal imaging approach was addressed to investigate bladder tumor proliferation longitudinally. The complementary abilities of Bioluminescence, High Resolution Ultrasound and Photo-acoustic Imaging permit a better understanding of bladder tumor development. Hybrid imaging modalities allow the integration of individual strengths to enable sensitive and improved quantification and understanding of tumor biology, and ultimately, can aid in the discovery and development of new therapeutics.

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VisualSonics FujiFilm

FujiFilm VisualSonics Inc. is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research.

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Photoacoustics is a ground-breaking, real time imaging modality for visualizing small animal anatomy and analyzing function in vivo and non-invasively

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