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Live animal imaging - Humane animal research

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Drawing on over 50 years of expertise in the life and animal sciences, Bruker designs preclinical imaging systems that...

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Learn what a researcher at the forefront of COVID-19 research has to say about his current research environment.

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Cell counters are tools for counting live and/or dead cells in a culture. Any researcher who works in a cell culture...

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Multi-modal molecular imaging driving pre-clinical research & pharmaceutical development

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Multi-modal molecular imaging at Massachusetts General Hospital – driving pre-clinical research and patient pathways...

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Extracellular vesicles (EVs) are lipid spheres released from cells. EVs express proteins and contain cargo that pertain...

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IncuCyte webinar : clonal heterogeneity promotes metabolite exchange to support pancreatic tumor

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Pancreatic ductaladenocarcinoma (PDA) is the third leading cause of cancer related death in the United States,...

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Analysis of single-cell transcriptomes in colorectal cancer

Feb 21, 2017

Scientists performed an unbiased analysis of functional diversity in colorectal cancer cells and their microenvironment using RNA-seq profiling of over 1,500 unsorted single cells from 11 primary tumors and matched normal mucosa (NM). To robustly interpret single-cell transcriptomes, we developed novel algorithms for normalizing expression estimates (pQ), clustering cells (RCA) and identifying differentially expressed genes (NODES). RCA identified 6 major cell types and multiple subtypes within colorectal samples.

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Fluidigm

Fluidigm is a Molecular and Single Cell Biology company that creates microfluidic-based chips and instrumentation for Life-Science research.

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The first automated solution for single-cell genomics, now capable of even more

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