PET/SPECT/CT preclinical imaging CUBES
Automated microscopy and Spatial Proteomics
Real-time, label free cell analysis
Nano and micro particle analysis
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Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar
Apr 25, 2024
The MARS® Bar Magnetic Separation Platform is a closed and automated isolation for cell therapy development and...
Spatial and temporal profiling of the complement system uncovered novel functions of the alternative
Apr 24, 2024
Mounting evidence implicated the classical complement pathway (CP) in normal brain development, and the pathogenesis of...
The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging
Apr 4, 2024
Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...
A microthrombus-driven fixed-point cleaved nanosystem for preventing post-thrombolysis recurrence
Apr 3, 2024
A thrombin-responsive and fixed-point cleaved Fu@pep-CLipo was developed for highly efficient and precise thrombolysis...
Webinar: Multimodal Assessment of Hypoxia in Tumors: From the Lab to the Clinic
Apr 2, 2024
25 April 2024, 4PM CET
This webinar will be of interest to multiple profiles in the community of biomedical...
Multiplexed tissue imaging using the Orion platform to reveal the Spatial Biology of Cancer
Mar 27, 2024
In this webinar Prof. Sandro Santagata, will reveal how Orion high-plex imaging and the use of this data, is valuable...
A 19-color single-tube Full Spectrum Flow Cytometry for the detection of Acute Myeloid Leukemia
Mar 13, 2024
This recent publication in Cytometry Part A describes the development and comprehensive workflow of a single-tube,...
18F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of NETs
Mar 11, 2024
A novel 18F-radiolabeled somatostatin analogue, [Al18F]NODA-MPAA-HTA, was synthesized and evaluated for positron...
Bacterial Lipopolysaccharides Exacerbate NHO Development
Oct 2, 2023
Neurogenic heterotopic ossifications (NHO) are heterotopic bones that develop in periarticular muscles after severe central nervous system (CNS) injuries. Several retrospective studies have shown that NHO prevalence is higher in patients who suffer concomitant infections. However, it is unclear whether these infections directly contribute to NHO development or reflect the immunodepression observed in patients with CNS injury. Using our mouse model of NHO induced by spinal cord injury (SCI) between vertebrae T11 to T13, we demonstrate that lipopolysaccharides (LPS) from gram-negative bacteria exacerbate NHO development in a toll-like receptor-4 (TLR4)-dependent manner, signaling through the TIR-domain-containing adapter-inducing interferon-β (TRIF/TICAM1) adaptor rather than the myeloid differentiation primary response-88 (MYD88) adaptor.
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First published: 21 August 2023
Related technologies: PET, SPECT, CT
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