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Feb 25, 2020
In individuals with compromised immune systems, C. albicans can cause life-threatening disseminated infections, and is known to be the predominant fungal pathogen of humans. As a means of causing infections, C. albicans forms biofilms, occurring on the surface of implanted medical devices and human tissues. Once developed, biofilm infections are difficult for the immune system to clear. They are highly resistant to antifungal agents, and are more resistant to antifungal treatment compared to planktonic cells. The mechanisms controlling this resistance are poorly understood. In this webinar, Craig will discuss how his lab has screened a comprehensive library of transcription factor deletion mutants to identify several novel regulators of biofilm resistance in C. albicans. Coupled with microfluidic experiments using the BioFlux 1000z system, this genetic screen has furthered our understanding of biofilm development and antifungal treatment resistance in these microbial communities.
Friday, February 28, 2020, 6:00 PM CET
Dr Craig Ennis, University of California
Related technologies: Cell interaction studies
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With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.
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www.fluxionbio.com
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