Accelerate to discover

Back to filter

Related topics

Assessment of myocardial dynamics using photoacoustics & cardiac elastography

VisualSonics FujiFilm

May 17, 2019

Are you interested in Principles of Photoacoustic (PA) Imaging, and its application in cardiovascular research? Don’t...

Webinar recording: Detecting cancer-associated structural variants using Bionano optical maps

BioNano Genomics

May 15, 2019

Bionano’s genome mapping technology directly observes long molecules from 150,000 bp to megabase pair lengths to...

PET/CT Si78: Versatility in microCT dose, speed, & resolution

Bruker Biospin

May 9, 2019

The Bruker PET/CT Si78 now pairs total-body PET and SkyScan microCT technology. This combination offers the advanced...

Cell by cell lung cancer marker profiling using high-parameter spectral flow cytometry

Cytek Biosciences

May 2, 2019

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 80-85% cases of lung cancer....

May 21, 2019

In Vivo Bioluminescence Imaging of Cobalt Accumulation in a Mouse Model

Spectral Instruments Imaging

Apr 26, 2019

As a trace element nutrient, cobalt is critical for both prokaryotes and eukaryotes. In the current study, a turn-on...

IncuCyte webinar recording: Human Neurons in vitro, next-gen models for neurological disease

Sartorius

Apr 23, 2019

The ability to generate and manipulate human neurons in vitro is an exciting advance that enables the validation,...

Synthesis and characterization of functional nanofilm-coated live Immune cells using CQ1

Yokogawa

Apr 10, 2019

Layer-by-layer assembly techniques have been extensively studied in cell biology because of their simplicity of...

May 21, 2019

Product update: The high pass plus cassette

Sage Science

Apr 9, 2019

The high pass plus gel cassette is the newest addition to the Pippin family. It is dedicated to the BluePippin...

Show all topics (10)

Cellular stress induces erythrocyte assembly and promotes microangiopathy

Dec 19, 2018

Researchers investigated the platelet-independent interaction between stressed erythrocytes and ULVWFs and its consequences for microcirculation and organ function under dynamic conditions. In response to shear stress, erythrocytes interacted strongly with VWF to initiate the formation of ULVWF/erythrocyteaggregates via the binding of Annexin V to the VWF A1 domain. VWF-erythrocyte adhesion was attenuated by heparin and the VWF-specific protease ADAMTS13. In an in vivo model of renal ischemia/reperfusion injury, erythrocytes adhered to capillaries of wild-type but not VWF-deficient mice and later resulted in less renal damage. In vivo imaging in mice confirmed the adhesion of stressed erythrocytes to the vessel wall. Moreover, enhanced eryptosis rates and increased VWF binding were detected in blood samples from patients with chronic renal failure. Our study demonstrates that stressed erythrocytes have a pronounced binding affinity to ULVWFs. The discovered mechanisms suggest that erythrocytes are essential for the pathogenesis of microangiopathies and renal damage by actively binding to ULVWFs.

Read more!

Scientific paper
Application

Related technologies: Cell interaction studies

Get more info

Riccardo Pasculli

Head of application support

Riccardo

Pasculli

+420 731 127 717

Send Message

Brand profile

Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

Related products

Core control system, integrated to any inverted microscope to introduce flow to your research

show detail

System that offers a fully-integrated solution for automated, high throughput shear flow assays

show detail

Measures microfluidic flow cell arrays in the dynamic environment instead of the stagnant

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey