Accelerate to discover

Back to filter

Related topics

Bruker announces software provider PMOD Technologies LLC

Bruker Biospin

Nov 13, 2020

PMOD Technologies aims to equip researchers with best-in-class software tools for biomedical imaging research in humans...

Microvascular injury in mild traumatic brain injury accelerates alzheimer-like pathogenesis in mice


Nov 9, 2020

Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD)....

CS-FNX Hitachi Koki, discover the state-of-art ultracentrifuges series

Hitachi Koki

Nov 4, 2020

Hitachi Koki, as a world leading producer of centrifuges offers general purpose floor standing and table top...

Live animal imaging - Humane animal research

Bruker Biospin

Oct 26, 2020

Drawing on over 50 years of expertise in the life and animal sciences, Bruker designs preclinical imaging systems that...

Nov 24, 2020

3D time lapse imaging and quantitative analysis of multilayered Endothelial cells migration


Oct 22, 2020

Time lapse confocal imaging has been an essential method to investigate the 3D dynamic behaviors of cells in tissue...

Meet the Expert - Brent Barre interview


Oct 21, 2020

Learn what a researcher at the forefront of COVID-19 research has to say about his current research environment.

Automated fever & hypothermia detection


Oct 14, 2020

As one of the oldest clinical indicators of disease in mammals, temperature is a crucial parameter to monitor,...

Nov 24, 2020

NorthernLights is now CE-IVD certified ! up to 34 colors for your clinical diagnostic use

Cytek Biosciences

Oct 7, 2020

Cytek Biosciences receives CE Marking on Its Northern Lights platform. A great move to make complete spectral flow...

Show all topics (10)

Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2

Nov 19, 2020

Dr Musil team, at UHKT in Prague, designed a semi-split vaccine prototype consisting of S protein-depleted viral particles and free S protein. Next, they investigated its immunogenic potential in BALB/c mice. The animals were immunized intradermally or intramuscularly with the dose adjusted with buffer or addition of aluminum hydroxide, respectively. The antibody response was evaluated by plasma analysis at 7 days after the first or second dose. The immune cell response was studied with Cytek Aurora spectral flow cytometer through analysis of splenocytes. The data showed a very early onset of both S protein-specific antibodies and virus-neutralizing antibodies at 90% inhibition regardless of the route of vaccine administration. However, significantly higher levels of neutralizing antibodies were detected in the intradermally (geometric mean titer - GMT of 7.8 ± 1.4) than in the intramuscularly immunized mice (GMT of 6.2 ± 1.5). In accordance with this, stimulation of cellular immunity by the semi-split vaccine was suggested by elevated levels of B and T lymphocyte subpopulations in the murine spleens. These responses were more predominant in the intradermally immunized mice compared with the intramuscular route of administration. The upward trend in the levels of plasmablasts, memory B cells, Th1 and Th2 lymphocytes, including follicular helper T cells, was confirmed even in mice receiving the vaccine intradermally at a dose of 0.5 μg.

Read the full paper!

Scientific paper
Technical breakthrough

Related technologies: Spectral flow cytometry

Get more info

Riccardo Pasculli

Head of application support



+420 731 127 717

Send Message

Brand profile

Cytek Biosciences

Cytek provides compact and affordable flow cytometry instruments with multiplexing capability that streamlines workflows and delivers a high level of biological clarity for a majority of applications.

Related products

Clinical spectral flow cytometer reaching 34 colors with three lasers... Is it possible?

show detail

A prodigy that takes flow cytometry to the next level, with up to five lasers and 64 fluorescence channels

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic