Accelerate to discover

Back to filter

Related topics

Introducing ExoFlex - The latest assay for customized EV detection

NanoView Biosciences

May 11, 2021

ExoFlex allows users to customize the detection of EVs via any custom antibody. Nanoview is offering the ability to...

Build your experiments online with new Spectrum Viewer and SpectroFlo Experiment Builder

Cytek Biosciences

May 5, 2021

Explore new capabilities of Cytek's Full Spectrum Viewer and complementary SpectroFlo Experiment Builder. Explore on...

Cytek Spectral cytometers : taking science one step further with 200+ Publications

Cytek Biosciences

Apr 26, 2021

Cytek Aurora is helping researchers around the world take their science further. See how in the 200+ publications in...

May 12, 2021

Cytek webinar : Evaluating Spectral Cytometry for Immune Profiling in Viral Disease

Cytek Biosciences

Apr 19, 2021

In conventional fluorescence cytometry, each fluorophore in a panel is measured in a target detector, through the use...

Observe the movement of live cells that make up living tissue in vivo

IVIM Technology

Apr 8, 2021

IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up...

Unleash Your Illumina Sequencer with TELL-Seq Linked Reads

Sage Science

Mar 24, 2021

Sage Science distributes universal sequencing technology´s TELL-Seq linked-read NGS library prep kits used with very...

May 12, 2021

A real time-saver, accurate cell counting in 15 seconds with C100 counter


Mar 17, 2021

Cell counters are tools for counting live and/or dead cells in a culture. Any researcher who works in a cell culture...

Show all topics (10)

Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2

Nov 19, 2020

Dr Musil team, at UHKT in Prague, designed a semi-split vaccine prototype consisting of S protein-depleted viral particles and free S protein. Next, they investigated its immunogenic potential in BALB/c mice. The animals were immunized intradermally or intramuscularly with the dose adjusted with buffer or addition of aluminum hydroxide, respectively. The antibody response was evaluated by plasma analysis at 7 days after the first or second dose. The immune cell response was studied with Cytek Aurora spectral flow cytometer through analysis of splenocytes. The data showed a very early onset of both S protein-specific antibodies and virus-neutralizing antibodies at 90% inhibition regardless of the route of vaccine administration. However, significantly higher levels of neutralizing antibodies were detected in the intradermally (geometric mean titer - GMT of 7.8 ± 1.4) than in the intramuscularly immunized mice (GMT of 6.2 ± 1.5). In accordance with this, stimulation of cellular immunity by the semi-split vaccine was suggested by elevated levels of B and T lymphocyte subpopulations in the murine spleens. These responses were more predominant in the intradermally immunized mice compared with the intramuscular route of administration. The upward trend in the levels of plasmablasts, memory B cells, Th1 and Th2 lymphocytes, including follicular helper T cells, was confirmed even in mice receiving the vaccine intradermally at a dose of 0.5 μg.

Read the full paper!

Scientific paper
Technical breakthrough

Related technologies: Spectral flow cytometry

Get more info

Riccardo Pasculli

Head of application support



+420 731 127 717

Send Message

Brand profile

Cytek Biosciences

Cytek provides compact and affordable flow cytometry instruments with multiplexing capability that streamlines workflows and delivers a high level of biological clarity for a majority of applications.

Related products

Clinical spectral flow cytometer reaching 34 colors with three lasers

show detail

A prodigy that takes flow cytometry to the next level, with up to five lasers and 64 fluorescence channels

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic